The stumble - From pipe cleaner to bone builder

Arthur L Swislocki, Jason A. Wexler

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective: To review the history of the transition of bisphosphonate use from bench chemistry to clinical applications. Methods: Pertinent medical literature, including limited-distribution as well as peer-reviewed publications, was reviewed. Results: Bisphosphonates were originally developed to interfere with calcium deposition. An expanded understanding of bone physiology, as well as a growing appreciation of bisphosphonate chemistry, allowed a broadening range of clinical applications. Conclusion: The use of bisphosphonates in clinical medicine depended on a series of fortuitous events that, at the time, were "stumbles," not unlike the discoveries of Fleming and Newton. The logical sequence is more apparent in retrospect.

Original languageEnglish (US)
Pages (from-to)194-197
Number of pages4
JournalEndocrine Practice
Issue number2
StatePublished - Mar 2007

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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