The state versus amyloid-β: The trial of the most wanted criminal in Alzheimer disease

Catherine Rottkamp, Craig S. Atwood, James A. Joseph, Akihiko Nunomura, George Perry, Mark A. Smith

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

Investigators studying the primary culprit responsible for Alzheimer disease have, for the past two decades, primarily focused on amyloid-β (Aβ). Here, we put Aβ on trial and review evidence amassed by the prosecution that implicate Aβ and also consider arguments and evidence gathered by the defense team who are convinced of the innocence of their client. As in all trials, the arguments provided by the prosecution and defense revolve around the same evidence, with opposing interpretations. Below, we present a brief synopsis of the trial for you, the jury, to decide the verdict. Amyloid-β: guilty or not-guilty?

Original languageEnglish (US)
Pages (from-to)1333-1341
Number of pages9
JournalPeptides
Volume23
Issue number7
DOIs
StatePublished - Jul 30 2002
Externally publishedYes

    Fingerprint

Keywords

  • Alzheimer disease
  • Cell death
  • Neurodegeneration
  • Neurotoxicity
  • Oxidative stress
  • Phosphorylated tau

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

Cite this

Rottkamp, C., Atwood, C. S., Joseph, J. A., Nunomura, A., Perry, G., & Smith, M. A. (2002). The state versus amyloid-β: The trial of the most wanted criminal in Alzheimer disease. Peptides, 23(7), 1333-1341. https://doi.org/10.1016/S0196-9781(02)00069-4