The state of regional therapy in the management of metastatic colorectal cancer to the liver

May Cho; Jun Gong; Marwan Fakih

doi:10.1586/14737140.2016.1129277

The state of regional therapy in the management of metastatic colorectal cancer to the liver

May Cho, Jun Gong, Marwan Fakih

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality in the United States. Most colorectal cancer patients die from advanced disease, and two-thirds of CRC deaths are due to liver metastases. Liver resection provides the best curative option for patients with colorectal liver metastases (CRLM), yet only 20% of those patients are eligible for liver metastases resection for curative intent. Loco-regional treatment of CRLM may provide additional benefits in terms of down-staging for resection and prolonged hepatic disease control. This review focusses on hepatic arterial infusion, radioembolization and chemoembolization.

Original language	English (US)
Pages (from-to)	229-245
Number of pages	17
Journal	Expert Review of Anticancer Therapy
Volume	16
Issue number	2
DOIs	https://doi.org/10.1586/14737140.2016.1129277
State	Published - Feb 1 2016
Externally published	Yes

Keywords

chemoembolization
hepatic artery infusion
liver metastases
radioembolization
Regional therapy

ASJC Scopus subject areas

Oncology
Pharmacology (medical)

Access to Document

10.1586/14737140.2016.1129277

Fingerprint Dive into the research topics of 'The state of regional therapy in the management of metastatic colorectal cancer to the liver'. Together they form a unique fingerprint.

Cite this

@article{3a32d066fd2f41a5b9f986e907302f35,

title = "The state of regional therapy in the management of metastatic colorectal cancer to the liver",

abstract = "Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality in the United States. Most colorectal cancer patients die from advanced disease, and two-thirds of CRC deaths are due to liver metastases. Liver resection provides the best curative option for patients with colorectal liver metastases (CRLM), yet only 20% of those patients are eligible for liver metastases resection for curative intent. Loco-regional treatment of CRLM may provide additional benefits in terms of down-staging for resection and prolonged hepatic disease control. This review focusses on hepatic arterial infusion, radioembolization and chemoembolization.",

keywords = "chemoembolization, hepatic artery infusion, liver metastases, radioembolization, Regional therapy",

author = "May Cho and Jun Gong and Marwan Fakih",

year = "2016",

month = feb,

day = "1",

doi = "10.1586/14737140.2016.1129277",

language = "English (US)",

volume = "16",

pages = "229--245",

journal = "Expert Review of Anticancer Therapy",

issn = "1473-7140",

publisher = "Expert Reviews Ltd.",

number = "2",

}

TY - JOUR

T1 - The state of regional therapy in the management of metastatic colorectal cancer to the liver

AU - Cho, May

AU - Gong, Jun

AU - Fakih, Marwan

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality in the United States. Most colorectal cancer patients die from advanced disease, and two-thirds of CRC deaths are due to liver metastases. Liver resection provides the best curative option for patients with colorectal liver metastases (CRLM), yet only 20% of those patients are eligible for liver metastases resection for curative intent. Loco-regional treatment of CRLM may provide additional benefits in terms of down-staging for resection and prolonged hepatic disease control. This review focusses on hepatic arterial infusion, radioembolization and chemoembolization.

AB - Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality in the United States. Most colorectal cancer patients die from advanced disease, and two-thirds of CRC deaths are due to liver metastases. Liver resection provides the best curative option for patients with colorectal liver metastases (CRLM), yet only 20% of those patients are eligible for liver metastases resection for curative intent. Loco-regional treatment of CRLM may provide additional benefits in terms of down-staging for resection and prolonged hepatic disease control. This review focusses on hepatic arterial infusion, radioembolization and chemoembolization.

KW - chemoembolization

KW - hepatic artery infusion

KW - liver metastases

KW - radioembolization

KW - Regional therapy

UR - http://www.scopus.com/inward/record.url?scp=84957434578&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957434578&partnerID=8YFLogxK

U2 - 10.1586/14737140.2016.1129277

DO - 10.1586/14737140.2016.1129277

M3 - Review article

C2 - 26652741

AN - SCOPUS:84957434578

VL - 16

SP - 229

EP - 245

JO - Expert Review of Anticancer Therapy

JF - Expert Review of Anticancer Therapy

SN - 1473-7140

IS - 2

ER -