The state of regional therapy in the management of metastatic colorectal cancer to the liver

May Cho; Jun Gong; Marwan Fakih

doi:10.1586/14737140.2016.1129277

The state of regional therapy in the management of metastatic colorectal cancer to the liver

May Cho, Jun Gong, Marwan Fakih

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality in the United States. Most colorectal cancer patients die from advanced disease, and two-thirds of CRC deaths are due to liver metastases. Liver resection provides the best curative option for patients with colorectal liver metastases (CRLM), yet only 20% of those patients are eligible for liver metastases resection for curative intent. Loco-regional treatment of CRLM may provide additional benefits in terms of down-staging for resection and prolonged hepatic disease control. This review focusses on hepatic arterial infusion, radioembolization and chemoembolization.

Original language	English (US)
Pages (from-to)	229-245
Number of pages	17
Journal	Expert Review of Anticancer Therapy
Volume	16
Issue number	2
DOIs	https://doi.org/10.1586/14737140.2016.1129277
State	Published - Feb 1 2016
Externally published	Yes

Keywords

chemoembolization
hepatic artery infusion
liver metastases
radioembolization
Regional therapy

ASJC Scopus subject areas

Oncology
Pharmacology (medical)

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abstract = "Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality in the United States. Most colorectal cancer patients die from advanced disease, and two-thirds of CRC deaths are due to liver metastases. Liver resection provides the best curative option for patients with colorectal liver metastases (CRLM), yet only 20% of those patients are eligible for liver metastases resection for curative intent. Loco-regional treatment of CRLM may provide additional benefits in terms of down-staging for resection and prolonged hepatic disease control. This review focusses on hepatic arterial infusion, radioembolization and chemoembolization.",

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AU - Cho, May

AU - Gong, Jun

AU - Fakih, Marwan

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N2 - Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality in the United States. Most colorectal cancer patients die from advanced disease, and two-thirds of CRC deaths are due to liver metastases. Liver resection provides the best curative option for patients with colorectal liver metastases (CRLM), yet only 20% of those patients are eligible for liver metastases resection for curative intent. Loco-regional treatment of CRLM may provide additional benefits in terms of down-staging for resection and prolonged hepatic disease control. This review focusses on hepatic arterial infusion, radioembolization and chemoembolization.

AB - Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality in the United States. Most colorectal cancer patients die from advanced disease, and two-thirds of CRC deaths are due to liver metastases. Liver resection provides the best curative option for patients with colorectal liver metastases (CRLM), yet only 20% of those patients are eligible for liver metastases resection for curative intent. Loco-regional treatment of CRLM may provide additional benefits in terms of down-staging for resection and prolonged hepatic disease control. This review focusses on hepatic arterial infusion, radioembolization and chemoembolization.

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KW - liver metastases

KW - radioembolization

KW - Regional therapy

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The state of regional therapy in the management of metastatic colorectal cancer to the liver

Abstract

Keywords

ASJC Scopus subject areas

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