The state of regional therapy in the management of metastatic colorectal cancer to the liver

May Cho, Jun Gong, Marwan Fakih

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality in the United States. Most colorectal cancer patients die from advanced disease, and two-thirds of CRC deaths are due to liver metastases. Liver resection provides the best curative option for patients with colorectal liver metastases (CRLM), yet only 20% of those patients are eligible for liver metastases resection for curative intent. Loco-regional treatment of CRLM may provide additional benefits in terms of down-staging for resection and prolonged hepatic disease control. This review focusses on hepatic arterial infusion, radioembolization and chemoembolization.

Original languageEnglish (US)
Pages (from-to)229-245
Number of pages17
JournalExpert Review of Anticancer Therapy
Volume16
Issue number2
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Keywords

  • chemoembolization
  • hepatic artery infusion
  • liver metastases
  • radioembolization
  • Regional therapy

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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