The state of hepatic artery infusion chemotherapy in the management of metastatic colorectal cancer to the liver

Marcia Leung, Sepideh Gholami

Research output: Contribution to journalReview article


Hepatic artery infusion (HAI) chemotherapy is a locoregional therapy for colorectal cancer liver metastasis that has been available since the 1980s. Multiple clinical trials have demonstrated the safety and efficacy of HAI with higher response rates compared to systemic chemotherapy alone. Clinical trials have shown the benefit of using HAI as a bridge to conversion to resection at a higher rate than systemic chemotherapy alone with rates as high as 60% in heavily pretreated patients. HAI in combination with systemic chemotherapy has also been associated with prolonged recurrence free survival and overall survival in the adjuvant setting. Specifically, the addition of HAI continues to show a benefit in prolonging overall survival, despite increased effectiveness of modern systemic chemotherapy (i.e., oxaliplatin and irinotecan). Lower recurrence and improved survival rates associated with HAI and systemic chemotherapy persist regardless of RAS mutational status.

Original languageEnglish (US)
Article number54
JournalChinese Clinical Oncology
Issue number5
StatePublished - Jan 1 2019



  • Biological tumor markers
  • Cancer chemotherapy agents
  • Colorectal cancer metastasis
  • Locoregional liver therapy

ASJC Scopus subject areas

  • Oncology

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