The solid-phase part of supported small-molecule synthesis

Mark J. Kurth

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The synthesis of small molecules on solid phase must not only address the vagaries of C-C-bond formation and functional-group manipulation, but must also take into account solid-support issues such as 'point of attachment', 'resin compatibility', 'reagent accesibility', and 'product liberation'. Hence, the resin plays a vital role in the solid-phase venture and the polymer advantages can be summarized as reactions can be driven to completion by addition of excess solution-phase reagents, reaction products are 'isolated' by filtration and washing, and multiple-step synthesis terminating with a 'selective' liberation step can deliver essentially pure product. These issues, as well as a number of strategies for the preparation and functionalization of resin supports, are discussed.

Original languageEnglish (US)
Pages (from-to)261-266
Number of pages6
JournalChimia
Volume50
Issue number6
StatePublished - 1996

ASJC Scopus subject areas

  • Chemistry(all)

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