The Sodium Channel Voltage Sensor Slides to Rest

Research output: Contribution to journalShort survey

1 Scopus citations

Abstract

Voltage-gated sodium channels (Navs) initiate the action potential waveforms in excitable cells. The molecular mechanisms controlling this process have been actively debated. New prokaryotic Nav structures by Wisedchaisri et al. have completed our understanding of the molecular conformations required for cellular electrical signaling, and provide key templates for research to examine eukaryotic Navs.

Original languageEnglish (US)
JournalTrends in Pharmacological Sciences
DOIs
StateAccepted/In press - Jan 1 2019

Keywords

  • gating charge
  • membrane protein
  • resting state
  • sodium channel
  • voltage-dependent channel gating
  • voltage-gated ion channel

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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