The smoking gun. Mechanism of methylprednisolone prevention of bleomycin-induced pulmonary fibrosis

W. J. Koenig, Carroll E Cross, T. W. Hesterberg, Jerold A Last

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We conclude that: 1) bleomycin-induced pulmonary fibrosis can be modified by large doses of MPS; 2) most histologic parameters of tissue injury are unchanged in MPS-treated animals despite a probable reduction in local cellular proliferation, and a significant reduction in inflammatory cell infiltration and collagen deposition; 3) bronchoalveolar lavage does not reflect the steroid-mediated decrease in inflammation and fibrosis; 4) MPS increases the percentage of neutrophils recovered by lavage in both bleomycin-treated and control animals; 5) MPS appears to prevent pulmonary fibrosis in the bleomycin model by suppressing cellular recruitment to sites of pulmonary injury and secondarily reducing local cellular proliferation and collagen synthesis at such sites.

Original languageEnglish (US)
JournalChest
Volume83
Issue number5 Suppl.
StatePublished - 1983

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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