The significance of receptor physiology for corticosterone-induced cleft palate in A/J mice

K. S. Brown; R. M. Hackman

The significance of receptor physiology for corticosterone-induced cleft palate in A/J mice

K. S. Brown, R. M. Hackman

Research output: Contribution to journal › Article › peer-review

Abstract

Mean plasma corticosterone levels of A/J mice rise from nonpregnant levels of 20.4 μg% to 40.6 μg% on day 11 and 167.11 μg% on day 14 of pregnancy. These changes in mean steroid levels are associated with proportionally increased diurnal swings. This suggests that the control mechanisms for diurnal swings respond in a proportional, rather than an absolute, way in regulating plasma hormone levels. Large diurnal hormone swings may be teratogenic or facilitate teratogenesis. The rules of receptor physiology may have wide application to the understanding of teratogenic risk.

Original language	English (US)
Pages (from-to)	299-304
Number of pages	6
Journal	Journal of Craniofacial Genetics and Developmental Biology
Volume	5
Issue number	SUPPL. 1
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Developmental Biology
Genetics
Medicine(all)

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