Abstract
Mean plasma corticosterone levels of A/J mice rise from nonpregnant levels of 20.4 μg% to 40.6 μg% on day 11 and 167.11 μg% on day 14 of pregnancy. These changes in mean steroid levels are associated with proportionally increased diurnal swings. This suggests that the control mechanisms for diurnal swings respond in a proportional, rather than an absolute, way in regulating plasma hormone levels. Large diurnal hormone swings may be teratogenic or facilitate teratogenesis. The rules of receptor physiology may have wide application to the understanding of teratogenic risk.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 299-304 |
| Number of pages | 6 |
| Journal | Journal of Craniofacial Genetics and Developmental Biology |
| Volume | 5 |
| Issue number | SUPPL. 1 |
| State | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Developmental Biology
- Genetics
- Medicine(all)
Cite this
The significance of receptor physiology for corticosterone-induced cleft palate in A/J mice. / Brown, K. S.; Hackman, R. M.
In: Journal of Craniofacial Genetics and Developmental Biology, Vol. 5, No. SUPPL. 1, 1985, p. 299-304.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The significance of receptor physiology for corticosterone-induced cleft palate in A/J mice
AU - Brown, K. S.
AU - Hackman, R. M.
PY - 1985
Y1 - 1985
N2 - Mean plasma corticosterone levels of A/J mice rise from nonpregnant levels of 20.4 μg% to 40.6 μg% on day 11 and 167.11 μg% on day 14 of pregnancy. These changes in mean steroid levels are associated with proportionally increased diurnal swings. This suggests that the control mechanisms for diurnal swings respond in a proportional, rather than an absolute, way in regulating plasma hormone levels. Large diurnal hormone swings may be teratogenic or facilitate teratogenesis. The rules of receptor physiology may have wide application to the understanding of teratogenic risk.
AB - Mean plasma corticosterone levels of A/J mice rise from nonpregnant levels of 20.4 μg% to 40.6 μg% on day 11 and 167.11 μg% on day 14 of pregnancy. These changes in mean steroid levels are associated with proportionally increased diurnal swings. This suggests that the control mechanisms for diurnal swings respond in a proportional, rather than an absolute, way in regulating plasma hormone levels. Large diurnal hormone swings may be teratogenic or facilitate teratogenesis. The rules of receptor physiology may have wide application to the understanding of teratogenic risk.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022227005&partnerID=8YFLogxK
M3 - Article
C2 - 3880514
AN - SCOPUS:0022227005
VL - 5
SP - 299
EP - 304
JO - Journal of Craniofacial Genetics and Developmental Biology
JF - Journal of Craniofacial Genetics and Developmental Biology
SN - 0270-4145
IS - SUPPL. 1
ER -