The signaling underlying FITness

Keith Baar

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Exercise results in highly specific physiological adaptations. Resistance exercise increases muscle mass and force production, while endurance exercise increases aerobic capacity. As the physical and chemical signals underlying this specificity become better understood, scientists are beginning to identify the key molecular effectors of exercise specificity. This review focuses on how variations in load, metabolic stress, and calcium flux are transduced to increases in muscle mass and endurance capacity. Specific attention is paid to the mammalian target of rapamycin, AMP-activated protein kinase, and the calcium-calmodulin-activated protein kinases, and the way these proteins interact during concurrent training.

Original languageEnglish (US)
Pages (from-to)411-419
Number of pages9
JournalApplied Physiology, Nutrition and Metabolism
Volume34
Issue number3
DOIs
StatePublished - Jun 2009
Externally publishedYes

Fingerprint

Calcium
Physiological Adaptation
Muscles
Physiological Stress
AMP-Activated Protein Kinases
Sirolimus
Calmodulin
Protein Kinases
Exercise
Proteins

Keywords

  • AMPK
  • CaMK
  • Concurrent training
  • Exercise
  • mTOR

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Physiology (medical)

Cite this

The signaling underlying FITness. / Baar, Keith.

In: Applied Physiology, Nutrition and Metabolism, Vol. 34, No. 3, 06.2009, p. 411-419.

Research output: Contribution to journalArticle

Baar, Keith. / The signaling underlying FITness. In: Applied Physiology, Nutrition and Metabolism. 2009 ; Vol. 34, No. 3. pp. 411-419.
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