TY - JOUR
T1 - The sex hormone profile of male patients with breast cancer
AU - Nirmul, D.
AU - Pegoraro, R. J.
AU - Jialal, I.
AU - Naidoo, C.
AU - Joubert, S. M.
PY - 1983
Y1 - 1983
N2 - The mean total serum oestradiol level was found to be significantly increased in 8 male patients with carcinoma of the breast when compared with 8 healthy reference subjects matched for race, sex and age. The calculated mean free oestradiol index was also higher in these patients. There were no significant differences, however, between the levels of LH, FSH, prolactin, DHEA-S, testosterone and SHGB in the 2 groups. The patients showed a significantly increased LH response to GnRH while there was no difference in the FSH response. Only 1/7 patients had a tumour devoid of steroid hormone receptors. It may be that an increased level of circulating oestradiol-17β is an important factor in the aetiology of hormone-dependent male breast cancer.
AB - The mean total serum oestradiol level was found to be significantly increased in 8 male patients with carcinoma of the breast when compared with 8 healthy reference subjects matched for race, sex and age. The calculated mean free oestradiol index was also higher in these patients. There were no significant differences, however, between the levels of LH, FSH, prolactin, DHEA-S, testosterone and SHGB in the 2 groups. The patients showed a significantly increased LH response to GnRH while there was no difference in the FSH response. Only 1/7 patients had a tumour devoid of steroid hormone receptors. It may be that an increased level of circulating oestradiol-17β is an important factor in the aetiology of hormone-dependent male breast cancer.
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U2 - 10.1038/bjc.1983.208
DO - 10.1038/bjc.1983.208
M3 - Article
C2 - 6684472
AN - SCOPUS:0020561868
VL - 48
SP - 423
EP - 427
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 3
ER -