The sex hormone profile of male patients with breast cancer

D. Nirmul, R. J. Pegoraro, I. Jialal, C. Naidoo, S. M. Joubert

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


The mean total serum oestradiol level was found to be significantly increased in 8 male patients with carcinoma of the breast when compared with 8 healthy reference subjects matched for race, sex and age. The calculated mean free oestradiol index was also higher in these patients. There were no significant differences, however, between the levels of LH, FSH, prolactin, DHEA-S, testosterone and SHGB in the 2 groups. The patients showed a significantly increased LH response to GnRH while there was no difference in the FSH response. Only 1/7 patients had a tumour devoid of steroid hormone receptors. It may be that an increased level of circulating oestradiol-17β is an important factor in the aetiology of hormone-dependent male breast cancer.

Original languageEnglish (US)
Pages (from-to)423-427
Number of pages5
JournalBritish Journal of Cancer
Issue number3
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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