The sensory cilia of Caenorhabditis elegans.

Peter N. Inglis, Guangshuo Ou, Michel R. Leroux, Jonathan M. Scholey

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

The non-motile cilium, once believed to be a vestigial cellular structure, is now increasingly associated with the ability of a wide variety of cells and organisms to sense their chemical and physical environments. With its limited number of sensory cilia and diverse behavioral repertoire, C. elegans has emerged as a powerful experimental system for studying how cilia are formed, function, and ultimately modulate complex behaviors. Here, we discuss the biogenesis, distribution, structures, composition and general functions of C. elegans cilia. We also briefly highlight how C. elegans is being used to provide molecular insights into various human ciliopathies, including Polycystic Kidney Disease and Bardet-Biedl Syndrome.

Original languageEnglish (US)
Pages (from-to)1-22
Number of pages22
JournalWormBook : the online review of C. elegans biology
StatePublished - 2007
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Inglis, P. N., Ou, G., Leroux, M. R., & Scholey, J. M. (2007). The sensory cilia of Caenorhabditis elegans. WormBook : the online review of C. elegans biology, 1-22.