TY - JOUR
T1 - The sensory cilia of Caenorhabditis elegans.
AU - Inglis, Peter N.
AU - Ou, Guangshuo
AU - Leroux, Michel R.
AU - Scholey, Jonathan M.
PY - 2007
Y1 - 2007
N2 - The non-motile cilium, once believed to be a vestigial cellular structure, is now increasingly associated with the ability of a wide variety of cells and organisms to sense their chemical and physical environments. With its limited number of sensory cilia and diverse behavioral repertoire, C. elegans has emerged as a powerful experimental system for studying how cilia are formed, function, and ultimately modulate complex behaviors. Here, we discuss the biogenesis, distribution, structures, composition and general functions of C. elegans cilia. We also briefly highlight how C. elegans is being used to provide molecular insights into various human ciliopathies, including Polycystic Kidney Disease and Bardet-Biedl Syndrome.
AB - The non-motile cilium, once believed to be a vestigial cellular structure, is now increasingly associated with the ability of a wide variety of cells and organisms to sense their chemical and physical environments. With its limited number of sensory cilia and diverse behavioral repertoire, C. elegans has emerged as a powerful experimental system for studying how cilia are formed, function, and ultimately modulate complex behaviors. Here, we discuss the biogenesis, distribution, structures, composition and general functions of C. elegans cilia. We also briefly highlight how C. elegans is being used to provide molecular insights into various human ciliopathies, including Polycystic Kidney Disease and Bardet-Biedl Syndrome.
UR - http://www.scopus.com/inward/record.url?scp=38449122706&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38449122706&partnerID=8YFLogxK
M3 - Article
C2 - 18050505
AN - SCOPUS:38449122706
SP - 1
EP - 22
JO - WormBook : the online review of C. elegans biology
JF - WormBook : the online review of C. elegans biology
SN - 1551-8507
ER -