The day of mating was designated as day zero of pregnancy. The pregnant animals received 5, 10, or 30 mg/kg of thalidomide orally, either as single doses on days 24, 25, 26, 27, 28, 29, or 51, or as multiple doses on days 25-27 of pregnancy. No malformations were observed following treatment on days 24, 29, and 51 of pregnancy. Malformations of the forelimbs were observed on days 25, 26, and 27, and both fore- and hindlimb malformations were observed following treatment on day 28. The malformations were characterized by total absence (amelia) or partial absence (meromelia) of the free limb.
|Original language||English (US)|
|Number of pages||10|
|Journal||Journal of Medical Primatology|
|State||Published - 1973|
ASJC Scopus subject areas
- Animal Science and Zoology