The self-assembling process and applications in tissue engineering

Jennifer K. Lee, Jarrett M. Link, Jerry C.Y. Hu, Kyriacos A. Athanasiou

Research output: Contribution to journalReview article

13 Scopus citations


Tissue engineering strives to create neotissues capable of restoring function. Scaffold-free technologies have emerged that can recapitulate native tissue function without the use of an exogenous scaffold. This review will survey, in particular, the self-assembling and self-organization processes as scaffold-free techniques. Characteristics and benefits of each process are described, and key examples of tissues created using these scaffold-free processes are examined to provide guidance for future tissue-engineering developments. We aim to explore the potential of self-assembly and self-organization scaffold-free approaches, detailing the recent progress in the in vitro tissue engineering of biomimetic tissues with these methods toward generating functional tissue replacements.

Original languageEnglish (US)
Article numbera025668
JournalCold Spring Harbor perspectives in medicine
Issue number11
StatePublished - Nov 1 2017
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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