Abstract
A total of 681 pregnant women were referred for evaluation of elevated maternal serum α-fetoprotein levels. Ultrasonographic examination yielded an explanation for the elevation of maternal serum α-fetoprotein in 42% of patients. Diagnoses made by ultrasonography included incorrect fetal dating, multiple gestation, fetal death, open neural tube defect, abdominal wall defect, placental abnormalities, cystic hygroma, renal anomalies, and oligohydramnios. Optimal prenatal diagnosis of fetal anomalies also requires the use of amniocentesis in many patients. Amniocentesis may be obviated if fetal dating is incorrect, if an unsuspected multiple gestation is discovered, or if there is a clear anomaly and the parents do not desire genetic counseling based on karyotype information. If the fetus appears normal, the ultrasonographic results are equivocal, or the parents desire more detailed genetic counseling when an anomaly is found by ultrasonography, then amniocentesis should be performed. Thirteen abnormalities were diagnosed by amniocentesis alone in this group.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1571-1576 |
| Number of pages | 6 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 164 |
| Issue number | 6 PART 1 |
| DOIs | |
| State | Published - 1991 |
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Keywords
- amniocentesis
- fetal ultrasonography
- Maternal serum α-fetoprotein
ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynecology
Cite this
The roles of ultrasonography and amniocentesis in evaluation of elevated maternal serum α-fetoprotein. / Lindfors, Karen K; Gorczyca, David P.; Hanson, Frederick W.; Tennant, Frances R.; McGahan, John P; Peterson, Ann G.
In: American Journal of Obstetrics and Gynecology, Vol. 164, No. 6 PART 1, 1991, p. 1571-1576.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The roles of ultrasonography and amniocentesis in evaluation of elevated maternal serum α-fetoprotein
AU - Lindfors, Karen K
AU - Gorczyca, David P.
AU - Hanson, Frederick W.
AU - Tennant, Frances R.
AU - McGahan, John P
AU - Peterson, Ann G.
PY - 1991
Y1 - 1991
N2 - A total of 681 pregnant women were referred for evaluation of elevated maternal serum α-fetoprotein levels. Ultrasonographic examination yielded an explanation for the elevation of maternal serum α-fetoprotein in 42% of patients. Diagnoses made by ultrasonography included incorrect fetal dating, multiple gestation, fetal death, open neural tube defect, abdominal wall defect, placental abnormalities, cystic hygroma, renal anomalies, and oligohydramnios. Optimal prenatal diagnosis of fetal anomalies also requires the use of amniocentesis in many patients. Amniocentesis may be obviated if fetal dating is incorrect, if an unsuspected multiple gestation is discovered, or if there is a clear anomaly and the parents do not desire genetic counseling based on karyotype information. If the fetus appears normal, the ultrasonographic results are equivocal, or the parents desire more detailed genetic counseling when an anomaly is found by ultrasonography, then amniocentesis should be performed. Thirteen abnormalities were diagnosed by amniocentesis alone in this group.
AB - A total of 681 pregnant women were referred for evaluation of elevated maternal serum α-fetoprotein levels. Ultrasonographic examination yielded an explanation for the elevation of maternal serum α-fetoprotein in 42% of patients. Diagnoses made by ultrasonography included incorrect fetal dating, multiple gestation, fetal death, open neural tube defect, abdominal wall defect, placental abnormalities, cystic hygroma, renal anomalies, and oligohydramnios. Optimal prenatal diagnosis of fetal anomalies also requires the use of amniocentesis in many patients. Amniocentesis may be obviated if fetal dating is incorrect, if an unsuspected multiple gestation is discovered, or if there is a clear anomaly and the parents do not desire genetic counseling based on karyotype information. If the fetus appears normal, the ultrasonographic results are equivocal, or the parents desire more detailed genetic counseling when an anomaly is found by ultrasonography, then amniocentesis should be performed. Thirteen abnormalities were diagnosed by amniocentesis alone in this group.
KW - amniocentesis
KW - fetal ultrasonography
KW - Maternal serum α-fetoprotein
UR - http://www.scopus.com/inward/record.url?scp=0025765229&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025765229&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(91)91438-3
DO - 10.1016/0002-9378(91)91438-3
M3 - Article
C2 - 1710874
AN - SCOPUS:0025765229
VL - 164
SP - 1571
EP - 1576
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 6 PART 1
ER -