A 12% (v/v) ethanol solution and, to a greater extent, wine fed to C3H male mice inhibited tumorigenesis in their liver and lungs induced by the carcinogen, ethyl carbamate. Ethyl carbamate (urethane), a water soluble carcinogen originally used for numerous commercial processes, is a contaminant of fermentation. Wine phenols used in these studies, i.e. caffeic acid, catechin hydrate, and gallic acid, without the presence of ethanol, appeared to enhance liver, but not lung, tumor incidence and frequency. Thus, outside of the presence of ethanol in wine, no other wine constituents have been identified that affords protection against cancer development of ethyl carbamate. Any cancer risk assessment of ethyl carbamate in wine should take into account this ethanol interaction.
|Original language||English (US)|
|Number of pages||7|
|Journal||ACS Symposium Series|
|Publication status||Published - 1997|
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