The Role of Wine in Ethyl Carbamate Induced Carcinogenesis Inhibition

Gilbert S. Stoewsand, J. L. Anderson, L. Munson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 12% (v/v) ethanol solution and, to a greater extent, wine fed to C3H male mice inhibited tumorigenesis in their liver and lungs induced by the carcinogen, ethyl carbamate. Ethyl carbamate (urethane), a water soluble carcinogen originally used for numerous commercial processes, is a contaminant of fermentation. Wine phenols used in these studies, i.e. caffeic acid, catechin hydrate, and gallic acid, without the presence of ethanol, appeared to enhance liver, but not lung, tumor incidence and frequency. Thus, outside of the presence of ethanol in wine, no other wine constituents have been identified that affords protection against cancer development of ethyl carbamate. Any cancer risk assessment of ethyl carbamate in wine should take into account this ethanol interaction.

Original languageEnglish (US)
Pages (from-to)230-236
Number of pages7
JournalACS Symposium Series
Volume661
StatePublished - 1997
Externally publishedYes

Fingerprint

Wine
Urethane
Ethanol
Carcinogens
Liver
Gallic Acid
Acids
Catechin
Phenols
Hydrates
Risk assessment
Fermentation
Tumors
Impurities
Water

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Stoewsand, G. S., Anderson, J. L., & Munson, L. (1997). The Role of Wine in Ethyl Carbamate Induced Carcinogenesis Inhibition. ACS Symposium Series, 661, 230-236.

The Role of Wine in Ethyl Carbamate Induced Carcinogenesis Inhibition. / Stoewsand, Gilbert S.; Anderson, J. L.; Munson, L.

In: ACS Symposium Series, Vol. 661, 1997, p. 230-236.

Research output: Contribution to journalArticle

Stoewsand, GS, Anderson, JL & Munson, L 1997, 'The Role of Wine in Ethyl Carbamate Induced Carcinogenesis Inhibition', ACS Symposium Series, vol. 661, pp. 230-236.
Stoewsand, Gilbert S. ; Anderson, J. L. ; Munson, L. / The Role of Wine in Ethyl Carbamate Induced Carcinogenesis Inhibition. In: ACS Symposium Series. 1997 ; Vol. 661. pp. 230-236.
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