The role of tissue engineering in articular cartilage repair and regeneration

Lijie Zhang, Jerry Hu, Kyriacos A. Athanasiou

Research output: Contribution to journalArticlepeer-review

269 Scopus citations


Articular cartilage repair and regeneration continue to be largely intractable because of the poor regenerative properties of this tissue. The field of articular cartilage tissue engineering, which aims to repair, regenerate, and/or improve injured or diseased articular cartilage functionality, has evoked intense interest and holds great potential for improving articular cartilage therapy. This review provides an overall description of the current state of and progress in articular cartilage repair and regeneration. Traditional therapies and related problems are introduced. More importantly, a variety of promising cell sources, biocompatible tissue engineered scaffolds, scaffoldless techniques, growth factors, and mechanical stimuli used in current articular cartilage tissue engineering are reviewed. Finally, the technical and regulatory challenges of articular cartilage tissue engineering and possible future directions are also discussed.

Original languageEnglish (US)
Pages (from-to)1-57
Number of pages57
JournalCritical Reviews in Biomedical Engineering
Issue number1-2
StatePublished - 2009


  • Articular cartilage
  • Bioactive factors
  • Cells
  • Regeneration
  • Regulatory affairs
  • Repair
  • Scaffolds
  • Self-assembly
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Biomedical Engineering


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