The role of the high-mobility group box1 protein–Toll like receptor pathway in diabetic vascular disease

Roma Pahwa, Ishwarlal Jialal

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Objectives: Increased Toll like receptors (TLRs) especially 2 and 4 have been demonstrated in obesity, metabolic syndrome (MetS) and diabetes resulting in increased cellular inflammation. Since we have shown increased TLR2 and 4 activities in both T1DM and T2DM and MetS, we wanted to elucidate the mechanisms of this sterile inflammation. In T1DM, T2DM and MetS we have shown that high mobility group box 1 protein (HMGB-1), a non-histone DNA binding protein is increased and could be a potential activator of TLRs since it has previously shown to activate TLR2, 4 and 9. We examined the role of HMGB-1 in patients and animal models of diabetes and MetS to determine how important it is as an activator of TLR mediated inflammation and its role in diabetic vascular complications. Methods: A Medline search was conducted using the terms HMGB-1, TLRs and diabetes. Results: HMGB-1 levels are increased in patients with diabetes and MetS, and associated with increased biomediators of inflammation. Furthermore data supported a role of HMGB-1 in both diabetic microvascular and macrovascular complications. Conclusions: HMGB-1 interaction with TLRs is implicated in diabetic complications and could be important therapeutic target.

Original languageEnglish (US)
Pages (from-to)1186-1191
Number of pages6
JournalJournal of Diabetes and its Complications
Volume30
Issue number6
DOIs
StatePublished - Aug 1 2016

Fingerprint

HMGB1 Protein
Diabetic Angiopathies
Toll-Like Receptors
Inflammation
Toll-Like Receptor 2
Toll-Like Receptor 4
DNA-Binding Proteins
Diabetes Complications
Animal Models
Obesity

Keywords

  • DAMPS
  • Diabetes
  • HMGB-1
  • Inflammation
  • Toll-like receptors
  • Vascular complications

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

The role of the high-mobility group box1 protein–Toll like receptor pathway in diabetic vascular disease. / Pahwa, Roma; Jialal, Ishwarlal.

In: Journal of Diabetes and its Complications, Vol. 30, No. 6, 01.08.2016, p. 1186-1191.

Research output: Contribution to journalReview article

@article{b3fcdcd2ae3b408b9248fd208638da31,
title = "The role of the high-mobility group box1 protein–Toll like receptor pathway in diabetic vascular disease",
abstract = "Objectives: Increased Toll like receptors (TLRs) especially 2 and 4 have been demonstrated in obesity, metabolic syndrome (MetS) and diabetes resulting in increased cellular inflammation. Since we have shown increased TLR2 and 4 activities in both T1DM and T2DM and MetS, we wanted to elucidate the mechanisms of this sterile inflammation. In T1DM, T2DM and MetS we have shown that high mobility group box 1 protein (HMGB-1), a non-histone DNA binding protein is increased and could be a potential activator of TLRs since it has previously shown to activate TLR2, 4 and 9. We examined the role of HMGB-1 in patients and animal models of diabetes and MetS to determine how important it is as an activator of TLR mediated inflammation and its role in diabetic vascular complications. Methods: A Medline search was conducted using the terms HMGB-1, TLRs and diabetes. Results: HMGB-1 levels are increased in patients with diabetes and MetS, and associated with increased biomediators of inflammation. Furthermore data supported a role of HMGB-1 in both diabetic microvascular and macrovascular complications. Conclusions: HMGB-1 interaction with TLRs is implicated in diabetic complications and could be important therapeutic target.",
keywords = "DAMPS, Diabetes, HMGB-1, Inflammation, Toll-like receptors, Vascular complications",
author = "Roma Pahwa and Ishwarlal Jialal",
year = "2016",
month = "8",
day = "1",
doi = "10.1016/j.jdiacomp.2016.03.005",
language = "English (US)",
volume = "30",
pages = "1186--1191",
journal = "Journal of Diabetes and its Complications",
issn = "1056-8727",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - The role of the high-mobility group box1 protein–Toll like receptor pathway in diabetic vascular disease

AU - Pahwa, Roma

AU - Jialal, Ishwarlal

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Objectives: Increased Toll like receptors (TLRs) especially 2 and 4 have been demonstrated in obesity, metabolic syndrome (MetS) and diabetes resulting in increased cellular inflammation. Since we have shown increased TLR2 and 4 activities in both T1DM and T2DM and MetS, we wanted to elucidate the mechanisms of this sterile inflammation. In T1DM, T2DM and MetS we have shown that high mobility group box 1 protein (HMGB-1), a non-histone DNA binding protein is increased and could be a potential activator of TLRs since it has previously shown to activate TLR2, 4 and 9. We examined the role of HMGB-1 in patients and animal models of diabetes and MetS to determine how important it is as an activator of TLR mediated inflammation and its role in diabetic vascular complications. Methods: A Medline search was conducted using the terms HMGB-1, TLRs and diabetes. Results: HMGB-1 levels are increased in patients with diabetes and MetS, and associated with increased biomediators of inflammation. Furthermore data supported a role of HMGB-1 in both diabetic microvascular and macrovascular complications. Conclusions: HMGB-1 interaction with TLRs is implicated in diabetic complications and could be important therapeutic target.

AB - Objectives: Increased Toll like receptors (TLRs) especially 2 and 4 have been demonstrated in obesity, metabolic syndrome (MetS) and diabetes resulting in increased cellular inflammation. Since we have shown increased TLR2 and 4 activities in both T1DM and T2DM and MetS, we wanted to elucidate the mechanisms of this sterile inflammation. In T1DM, T2DM and MetS we have shown that high mobility group box 1 protein (HMGB-1), a non-histone DNA binding protein is increased and could be a potential activator of TLRs since it has previously shown to activate TLR2, 4 and 9. We examined the role of HMGB-1 in patients and animal models of diabetes and MetS to determine how important it is as an activator of TLR mediated inflammation and its role in diabetic vascular complications. Methods: A Medline search was conducted using the terms HMGB-1, TLRs and diabetes. Results: HMGB-1 levels are increased in patients with diabetes and MetS, and associated with increased biomediators of inflammation. Furthermore data supported a role of HMGB-1 in both diabetic microvascular and macrovascular complications. Conclusions: HMGB-1 interaction with TLRs is implicated in diabetic complications and could be important therapeutic target.

KW - DAMPS

KW - Diabetes

KW - HMGB-1

KW - Inflammation

KW - Toll-like receptors

KW - Vascular complications

UR - http://www.scopus.com/inward/record.url?scp=84962257803&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962257803&partnerID=8YFLogxK

U2 - 10.1016/j.jdiacomp.2016.03.005

DO - 10.1016/j.jdiacomp.2016.03.005

M3 - Review article

AN - SCOPUS:84962257803

VL - 30

SP - 1186

EP - 1191

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

SN - 1056-8727

IS - 6

ER -