The role of T cells in primary biliary cirrhosis

Judith A Van de Water, Shinji Shimoda, Yoshiyuki Niho, Ross Coppel, Aftab Ansari, M. Eric Gershwin

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

While fervently studied by several laboratories, the role of T cells in the pathogenesis of primary biliary cirrhosis (PBC) still remains a mystery. The studies concerning cell phenotype, antigen specificity, and major histocompatibility complex (MHC) T-cell receptor (TCR) interaction gathered thus far all address important aspects of this intriguing conundrum. However, the lack of an animal model and the genetic diversity of the human population with PBC make this task even more difficult. The possibilities regarding immune therapy resulting from such studies are of great importance. Future work concerning the T-cell epitopes-for both the pyruvate dehydrogenase complex (PDC), its related mitochondrial autoantigens, and any as yet unidentified PBC-specific autoantigens-may provide valuable information with regard to disease therapy. In addition, knowledge with regard to TCR usage and MHC association will help to clarify the pathogenic mechanisms of this enigmatic disease.

Original languageEnglish (US)
Pages (from-to)105-113
Number of pages9
JournalSeminars in Liver Disease
Volume17
Issue number2
StatePublished - May 1997

Keywords

  • Liver
  • Primary biliary cirrhosis
  • Pyruvate dehydrogenase
  • T cells
  • T-cell receptor

ASJC Scopus subject areas

  • Hepatology

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    Van de Water, J. A., Shimoda, S., Niho, Y., Coppel, R., Ansari, A., & Gershwin, M. E. (1997). The role of T cells in primary biliary cirrhosis. Seminars in Liver Disease, 17(2), 105-113.