The role of T cells in primary biliary cirrhosis

Judith A Van de Water, Shinji Shimoda, Yoshiyuki Niho, Ross Coppel, Aftab Ansari, M. Eric Gershwin

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

While fervently studied by several laboratories, the role of T cells in the pathogenesis of primary biliary cirrhosis (PBC) still remains a mystery. The studies concerning cell phenotype, antigen specificity, and major histocompatibility complex (MHC) T-cell receptor (TCR) interaction gathered thus far all address important aspects of this intriguing conundrum. However, the lack of an animal model and the genetic diversity of the human population with PBC make this task even more difficult. The possibilities regarding immune therapy resulting from such studies are of great importance. Future work concerning the T-cell epitopes-for both the pyruvate dehydrogenase complex (PDC), its related mitochondrial autoantigens, and any as yet unidentified PBC-specific autoantigens-may provide valuable information with regard to disease therapy. In addition, knowledge with regard to TCR usage and MHC association will help to clarify the pathogenic mechanisms of this enigmatic disease.

Original languageEnglish (US)
Pages (from-to)105-113
Number of pages9
JournalSeminars in Liver Disease
Volume17
Issue number2
StatePublished - May 1997

Fingerprint

Biliary Liver Cirrhosis
Autoantigens
T-Cell Antigen Receptor
Major Histocompatibility Complex
T-Lymphocytes
Pyruvate Dehydrogenase Complex
T-Lymphocyte Epitopes
Cell Communication
Animal Models
Phenotype
Antigens
Therapeutics
Population

Keywords

  • Liver
  • Primary biliary cirrhosis
  • Pyruvate dehydrogenase
  • T cells
  • T-cell receptor

ASJC Scopus subject areas

  • Hepatology

Cite this

Van de Water, J. A., Shimoda, S., Niho, Y., Coppel, R., Ansari, A., & Gershwin, M. E. (1997). The role of T cells in primary biliary cirrhosis. Seminars in Liver Disease, 17(2), 105-113.

The role of T cells in primary biliary cirrhosis. / Van de Water, Judith A; Shimoda, Shinji; Niho, Yoshiyuki; Coppel, Ross; Ansari, Aftab; Gershwin, M. Eric.

In: Seminars in Liver Disease, Vol. 17, No. 2, 05.1997, p. 105-113.

Research output: Contribution to journalArticle

Van de Water, JA, Shimoda, S, Niho, Y, Coppel, R, Ansari, A & Gershwin, ME 1997, 'The role of T cells in primary biliary cirrhosis', Seminars in Liver Disease, vol. 17, no. 2, pp. 105-113.
Van de Water JA, Shimoda S, Niho Y, Coppel R, Ansari A, Gershwin ME. The role of T cells in primary biliary cirrhosis. Seminars in Liver Disease. 1997 May;17(2):105-113.
Van de Water, Judith A ; Shimoda, Shinji ; Niho, Yoshiyuki ; Coppel, Ross ; Ansari, Aftab ; Gershwin, M. Eric. / The role of T cells in primary biliary cirrhosis. In: Seminars in Liver Disease. 1997 ; Vol. 17, No. 2. pp. 105-113.
@article{55be0b415aa0483db4979c8b47eaeda8,
title = "The role of T cells in primary biliary cirrhosis",
abstract = "While fervently studied by several laboratories, the role of T cells in the pathogenesis of primary biliary cirrhosis (PBC) still remains a mystery. The studies concerning cell phenotype, antigen specificity, and major histocompatibility complex (MHC) T-cell receptor (TCR) interaction gathered thus far all address important aspects of this intriguing conundrum. However, the lack of an animal model and the genetic diversity of the human population with PBC make this task even more difficult. The possibilities regarding immune therapy resulting from such studies are of great importance. Future work concerning the T-cell epitopes-for both the pyruvate dehydrogenase complex (PDC), its related mitochondrial autoantigens, and any as yet unidentified PBC-specific autoantigens-may provide valuable information with regard to disease therapy. In addition, knowledge with regard to TCR usage and MHC association will help to clarify the pathogenic mechanisms of this enigmatic disease.",
keywords = "Liver, Primary biliary cirrhosis, Pyruvate dehydrogenase, T cells, T-cell receptor",
author = "{Van de Water}, {Judith A} and Shinji Shimoda and Yoshiyuki Niho and Ross Coppel and Aftab Ansari and Gershwin, {M. Eric}",
year = "1997",
month = "5",
language = "English (US)",
volume = "17",
pages = "105--113",
journal = "Seminars in Liver Disease",
issn = "0272-8087",
publisher = "Thieme Medical Publishers",
number = "2",

}

TY - JOUR

T1 - The role of T cells in primary biliary cirrhosis

AU - Van de Water, Judith A

AU - Shimoda, Shinji

AU - Niho, Yoshiyuki

AU - Coppel, Ross

AU - Ansari, Aftab

AU - Gershwin, M. Eric

PY - 1997/5

Y1 - 1997/5

N2 - While fervently studied by several laboratories, the role of T cells in the pathogenesis of primary biliary cirrhosis (PBC) still remains a mystery. The studies concerning cell phenotype, antigen specificity, and major histocompatibility complex (MHC) T-cell receptor (TCR) interaction gathered thus far all address important aspects of this intriguing conundrum. However, the lack of an animal model and the genetic diversity of the human population with PBC make this task even more difficult. The possibilities regarding immune therapy resulting from such studies are of great importance. Future work concerning the T-cell epitopes-for both the pyruvate dehydrogenase complex (PDC), its related mitochondrial autoantigens, and any as yet unidentified PBC-specific autoantigens-may provide valuable information with regard to disease therapy. In addition, knowledge with regard to TCR usage and MHC association will help to clarify the pathogenic mechanisms of this enigmatic disease.

AB - While fervently studied by several laboratories, the role of T cells in the pathogenesis of primary biliary cirrhosis (PBC) still remains a mystery. The studies concerning cell phenotype, antigen specificity, and major histocompatibility complex (MHC) T-cell receptor (TCR) interaction gathered thus far all address important aspects of this intriguing conundrum. However, the lack of an animal model and the genetic diversity of the human population with PBC make this task even more difficult. The possibilities regarding immune therapy resulting from such studies are of great importance. Future work concerning the T-cell epitopes-for both the pyruvate dehydrogenase complex (PDC), its related mitochondrial autoantigens, and any as yet unidentified PBC-specific autoantigens-may provide valuable information with regard to disease therapy. In addition, knowledge with regard to TCR usage and MHC association will help to clarify the pathogenic mechanisms of this enigmatic disease.

KW - Liver

KW - Primary biliary cirrhosis

KW - Pyruvate dehydrogenase

KW - T cells

KW - T-cell receptor

UR - http://www.scopus.com/inward/record.url?scp=0030900830&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030900830&partnerID=8YFLogxK

M3 - Article

VL - 17

SP - 105

EP - 113

JO - Seminars in Liver Disease

JF - Seminars in Liver Disease

SN - 0272-8087

IS - 2

ER -