The role of surgery in treatment of stage IV melanoma

Shawn E. Young, Steve R. Martinez, Richard Essner

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The prognosis for patients with melanoma has not improved over the last 30 years. So far, almost without exception, clinical trials conducted with single or multiple agent chemotherapy, biological therapy (interferon-alpha, interleukin-2), and biochemotherapy have failed to demonstrate consistent survival benefit. Without effective alternate treatments, surgery must be considered the primary treatment of melanoma, independent of disease stage. Although surgery is clearly favored as the treatment of localized melanoma, consensus opinion and clinician preference become divided once melanoma progresses beyond its primary site. Many physicians will adopt an attitude of resignation and hesitancy when treating metastatic melanoma. As a result, patients with advanced disease are often treated with medications that produce little survival or palliative benefit at the expense of significant toxicity. Numerous studies have demonstrated clear and durable survival advantages for patients undergoing complete resection of metastatic melanoma. Further, surgical resection can produce an immediate decrease in tumor burden with minimal morbidity and mortality at a reasonable cost.

Original languageEnglish (US)
Pages (from-to)344-351
Number of pages8
JournalJournal of Surgical Oncology
Volume94
Issue number4
DOIs
StatePublished - Sep 15 2006
Externally publishedYes

Fingerprint

Melanoma
Survival
Therapeutics
Biological Therapy
Tumor Burden
Interferon-alpha
Interleukin-2
Consensus
Clinical Trials
Morbidity
Physicians
Costs and Cost Analysis
Drug Therapy
Mortality

Keywords

  • Melanoma
  • Metastases
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

The role of surgery in treatment of stage IV melanoma. / Young, Shawn E.; Martinez, Steve R.; Essner, Richard.

In: Journal of Surgical Oncology, Vol. 94, No. 4, 15.09.2006, p. 344-351.

Research output: Contribution to journalArticle

Young, SE, Martinez, SR & Essner, R 2006, 'The role of surgery in treatment of stage IV melanoma', Journal of Surgical Oncology, vol. 94, no. 4, pp. 344-351. https://doi.org/10.1002/jso.20303
Young, Shawn E. ; Martinez, Steve R. ; Essner, Richard. / The role of surgery in treatment of stage IV melanoma. In: Journal of Surgical Oncology. 2006 ; Vol. 94, No. 4. pp. 344-351.
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