The role of oxidized low density lipoprotein in atherogenesis

Ishwarlal Jialal, Sridevi Devaraj

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for atherosclerotic disease. Although the precise mechanism(s) via which LDL promotes atherogenesis remains to be elucidated, the oxidative modification of LDL may be a crucial mechanism. Several lines of evidence support a role for oxidatively modified LDL in atherogenesis. LDL can be oxidatively modified in cell-free systems by transition metals and by all the major cells of the arterial wall. Oxidatively modified LDL (Ox-LDL) is taken up by macrophage scavenger receptors, promoting cholesterol ester accumulation and foam cell formation. It also promotes atherosclerosis by recruitment and retention of monocytes in the intima, by its cytotoxicity toward endothelial cells and by stimulating monocyte adhesion to the endothelium. Several lines of evidence support the in vivo existence of Ox- LDL. The LDL of patients with atherosclerosis are more prone to oxidation; antibodies against epitopes on Ox-LDL have been positively correlated with the progression of atherosclerosis. The oxidation of LDL has been shown to be reduced by antioxidants, and in animal models, these antioxidants decrease atherosclerotic lesion formation. Thus, much evidence supports a role for oxidized LDL in atherogenesis.

Original languageEnglish (US)
JournalJournal of Nutrition
Volume126
Issue number4 SUPPL.
StatePublished - 1996
Externally publishedYes

Fingerprint

atherogenesis
low density lipoprotein
LDL Lipoproteins
Atherosclerosis
atherosclerosis
Monocytes
monocytes
Antioxidants
transition elements
Scavenger Receptors
oxidation
Foam Cells
foam cells
Cell-Free System
antioxidants
oxidized low density lipoprotein
Cholesterol Esters
cell free system
oxen
cholesteryl esters

Keywords

  • antioxidants
  • atherogenesis
  • oxidized LDL

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

The role of oxidized low density lipoprotein in atherogenesis. / Jialal, Ishwarlal; Devaraj, Sridevi.

In: Journal of Nutrition, Vol. 126, No. 4 SUPPL., 1996.

Research output: Contribution to journalArticle

Jialal, I & Devaraj, S 1996, 'The role of oxidized low density lipoprotein in atherogenesis', Journal of Nutrition, vol. 126, no. 4 SUPPL..
Jialal, Ishwarlal ; Devaraj, Sridevi. / The role of oxidized low density lipoprotein in atherogenesis. In: Journal of Nutrition. 1996 ; Vol. 126, No. 4 SUPPL.
@article{271f7f4563cf406bbd9728eb2161110b,
title = "The role of oxidized low density lipoprotein in atherogenesis",
abstract = "An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for atherosclerotic disease. Although the precise mechanism(s) via which LDL promotes atherogenesis remains to be elucidated, the oxidative modification of LDL may be a crucial mechanism. Several lines of evidence support a role for oxidatively modified LDL in atherogenesis. LDL can be oxidatively modified in cell-free systems by transition metals and by all the major cells of the arterial wall. Oxidatively modified LDL (Ox-LDL) is taken up by macrophage scavenger receptors, promoting cholesterol ester accumulation and foam cell formation. It also promotes atherosclerosis by recruitment and retention of monocytes in the intima, by its cytotoxicity toward endothelial cells and by stimulating monocyte adhesion to the endothelium. Several lines of evidence support the in vivo existence of Ox- LDL. The LDL of patients with atherosclerosis are more prone to oxidation; antibodies against epitopes on Ox-LDL have been positively correlated with the progression of atherosclerosis. The oxidation of LDL has been shown to be reduced by antioxidants, and in animal models, these antioxidants decrease atherosclerotic lesion formation. Thus, much evidence supports a role for oxidized LDL in atherogenesis.",
keywords = "antioxidants, atherogenesis, oxidized LDL",
author = "Ishwarlal Jialal and Sridevi Devaraj",
year = "1996",
language = "English (US)",
volume = "126",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "4 SUPPL.",

}

TY - JOUR

T1 - The role of oxidized low density lipoprotein in atherogenesis

AU - Jialal, Ishwarlal

AU - Devaraj, Sridevi

PY - 1996

Y1 - 1996

N2 - An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for atherosclerotic disease. Although the precise mechanism(s) via which LDL promotes atherogenesis remains to be elucidated, the oxidative modification of LDL may be a crucial mechanism. Several lines of evidence support a role for oxidatively modified LDL in atherogenesis. LDL can be oxidatively modified in cell-free systems by transition metals and by all the major cells of the arterial wall. Oxidatively modified LDL (Ox-LDL) is taken up by macrophage scavenger receptors, promoting cholesterol ester accumulation and foam cell formation. It also promotes atherosclerosis by recruitment and retention of monocytes in the intima, by its cytotoxicity toward endothelial cells and by stimulating monocyte adhesion to the endothelium. Several lines of evidence support the in vivo existence of Ox- LDL. The LDL of patients with atherosclerosis are more prone to oxidation; antibodies against epitopes on Ox-LDL have been positively correlated with the progression of atherosclerosis. The oxidation of LDL has been shown to be reduced by antioxidants, and in animal models, these antioxidants decrease atherosclerotic lesion formation. Thus, much evidence supports a role for oxidized LDL in atherogenesis.

AB - An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for atherosclerotic disease. Although the precise mechanism(s) via which LDL promotes atherogenesis remains to be elucidated, the oxidative modification of LDL may be a crucial mechanism. Several lines of evidence support a role for oxidatively modified LDL in atherogenesis. LDL can be oxidatively modified in cell-free systems by transition metals and by all the major cells of the arterial wall. Oxidatively modified LDL (Ox-LDL) is taken up by macrophage scavenger receptors, promoting cholesterol ester accumulation and foam cell formation. It also promotes atherosclerosis by recruitment and retention of monocytes in the intima, by its cytotoxicity toward endothelial cells and by stimulating monocyte adhesion to the endothelium. Several lines of evidence support the in vivo existence of Ox- LDL. The LDL of patients with atherosclerosis are more prone to oxidation; antibodies against epitopes on Ox-LDL have been positively correlated with the progression of atherosclerosis. The oxidation of LDL has been shown to be reduced by antioxidants, and in animal models, these antioxidants decrease atherosclerotic lesion formation. Thus, much evidence supports a role for oxidized LDL in atherogenesis.

KW - antioxidants

KW - atherogenesis

KW - oxidized LDL

UR - http://www.scopus.com/inward/record.url?scp=0029965477&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029965477&partnerID=8YFLogxK

M3 - Article

VL - 126

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 4 SUPPL.

ER -