The role of organochlorines in cancer-associated mortality in California sea lions (Zalophus californianus)

Gina M. Ylitalo, John E. Stein, Tom Hom, Lyndal L. Johnson, Karen L. Tilbury, Ailsa J. Hall, Teri Rowles, Denise Greig, Linda J Lowenstine, Frances M D Gulland

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Wild California sea lions (Zalophus californianus) have an unusually high prevalence of neoplasms (18% of stranded dead adults) and high levels of contaminants. The contribution of organochlorine (OC) tissue burdens to the probability of sea lions dying from carcinoma was explored using a logistic regression model. Levels of PCBs and DDTs were determined in blubber of sea lions diagnosed with metastatic carcinoma and animals that had died from non-carcinoma-related incidents (e.g., gunshot, domoic acid poisoning). Animals with carcinoma had higher mean concentrations (based on wet weight) of PCBs and DDTs (more than 85% and 30% higher, respectively) in blubber than did sea lions without carcinoma; the highest concentrations of OCs in the sea lions affected with carcinoma were measured in the males. Blubber thickness was significantly different between the two groups of sea lions, but after controlling for this difference, there was still a significant effect of PCBs, but not DDTs, on the probability of sea lions dying with carcinoma. Age, sex, mass and length did not affect the probability of dying from carcinoma.

Original languageEnglish (US)
Pages (from-to)30-39
Number of pages10
JournalMarine Pollution Bulletin
Volume50
Issue number1
DOIs
StatePublished - Jan 2005

Fingerprint

pinniped
Polychlorinated biphenyls
Otariidae
organochlorine
carcinoma
cancer
mortality
neoplasms
blubber
Animals
DDT
PCB
Logistics
Impurities
Tissue
Acids
domoic acid
animal
Zalophus californianus
poisoning

Keywords

  • California sea lions
  • Carcinoma
  • Marine mammals
  • Organochlorines

ASJC Scopus subject areas

  • Aquatic Science
  • Oceanography
  • Pollution

Cite this

Ylitalo, G. M., Stein, J. E., Hom, T., Johnson, L. L., Tilbury, K. L., Hall, A. J., ... Gulland, F. M. D. (2005). The role of organochlorines in cancer-associated mortality in California sea lions (Zalophus californianus). Marine Pollution Bulletin, 50(1), 30-39. https://doi.org/10.1016/j.marpolbul.2004.08.005

The role of organochlorines in cancer-associated mortality in California sea lions (Zalophus californianus). / Ylitalo, Gina M.; Stein, John E.; Hom, Tom; Johnson, Lyndal L.; Tilbury, Karen L.; Hall, Ailsa J.; Rowles, Teri; Greig, Denise; Lowenstine, Linda J; Gulland, Frances M D.

In: Marine Pollution Bulletin, Vol. 50, No. 1, 01.2005, p. 30-39.

Research output: Contribution to journalArticle

Ylitalo, GM, Stein, JE, Hom, T, Johnson, LL, Tilbury, KL, Hall, AJ, Rowles, T, Greig, D, Lowenstine, LJ & Gulland, FMD 2005, 'The role of organochlorines in cancer-associated mortality in California sea lions (Zalophus californianus)', Marine Pollution Bulletin, vol. 50, no. 1, pp. 30-39. https://doi.org/10.1016/j.marpolbul.2004.08.005
Ylitalo, Gina M. ; Stein, John E. ; Hom, Tom ; Johnson, Lyndal L. ; Tilbury, Karen L. ; Hall, Ailsa J. ; Rowles, Teri ; Greig, Denise ; Lowenstine, Linda J ; Gulland, Frances M D. / The role of organochlorines in cancer-associated mortality in California sea lions (Zalophus californianus). In: Marine Pollution Bulletin. 2005 ; Vol. 50, No. 1. pp. 30-39.
@article{d2fc54f4dfe04a06989bc1f516b03e72,
title = "The role of organochlorines in cancer-associated mortality in California sea lions (Zalophus californianus)",
abstract = "Wild California sea lions (Zalophus californianus) have an unusually high prevalence of neoplasms (18{\%} of stranded dead adults) and high levels of contaminants. The contribution of organochlorine (OC) tissue burdens to the probability of sea lions dying from carcinoma was explored using a logistic regression model. Levels of PCBs and DDTs were determined in blubber of sea lions diagnosed with metastatic carcinoma and animals that had died from non-carcinoma-related incidents (e.g., gunshot, domoic acid poisoning). Animals with carcinoma had higher mean concentrations (based on wet weight) of PCBs and DDTs (more than 85{\%} and 30{\%} higher, respectively) in blubber than did sea lions without carcinoma; the highest concentrations of OCs in the sea lions affected with carcinoma were measured in the males. Blubber thickness was significantly different between the two groups of sea lions, but after controlling for this difference, there was still a significant effect of PCBs, but not DDTs, on the probability of sea lions dying with carcinoma. Age, sex, mass and length did not affect the probability of dying from carcinoma.",
keywords = "California sea lions, Carcinoma, Marine mammals, Organochlorines",
author = "Ylitalo, {Gina M.} and Stein, {John E.} and Tom Hom and Johnson, {Lyndal L.} and Tilbury, {Karen L.} and Hall, {Ailsa J.} and Teri Rowles and Denise Greig and Lowenstine, {Linda J} and Gulland, {Frances M D}",
year = "2005",
month = "1",
doi = "10.1016/j.marpolbul.2004.08.005",
language = "English (US)",
volume = "50",
pages = "30--39",
journal = "Marine Pollution Bulletin",
issn = "0025-326X",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - The role of organochlorines in cancer-associated mortality in California sea lions (Zalophus californianus)

AU - Ylitalo, Gina M.

AU - Stein, John E.

AU - Hom, Tom

AU - Johnson, Lyndal L.

AU - Tilbury, Karen L.

AU - Hall, Ailsa J.

AU - Rowles, Teri

AU - Greig, Denise

AU - Lowenstine, Linda J

AU - Gulland, Frances M D

PY - 2005/1

Y1 - 2005/1

N2 - Wild California sea lions (Zalophus californianus) have an unusually high prevalence of neoplasms (18% of stranded dead adults) and high levels of contaminants. The contribution of organochlorine (OC) tissue burdens to the probability of sea lions dying from carcinoma was explored using a logistic regression model. Levels of PCBs and DDTs were determined in blubber of sea lions diagnosed with metastatic carcinoma and animals that had died from non-carcinoma-related incidents (e.g., gunshot, domoic acid poisoning). Animals with carcinoma had higher mean concentrations (based on wet weight) of PCBs and DDTs (more than 85% and 30% higher, respectively) in blubber than did sea lions without carcinoma; the highest concentrations of OCs in the sea lions affected with carcinoma were measured in the males. Blubber thickness was significantly different between the two groups of sea lions, but after controlling for this difference, there was still a significant effect of PCBs, but not DDTs, on the probability of sea lions dying with carcinoma. Age, sex, mass and length did not affect the probability of dying from carcinoma.

AB - Wild California sea lions (Zalophus californianus) have an unusually high prevalence of neoplasms (18% of stranded dead adults) and high levels of contaminants. The contribution of organochlorine (OC) tissue burdens to the probability of sea lions dying from carcinoma was explored using a logistic regression model. Levels of PCBs and DDTs were determined in blubber of sea lions diagnosed with metastatic carcinoma and animals that had died from non-carcinoma-related incidents (e.g., gunshot, domoic acid poisoning). Animals with carcinoma had higher mean concentrations (based on wet weight) of PCBs and DDTs (more than 85% and 30% higher, respectively) in blubber than did sea lions without carcinoma; the highest concentrations of OCs in the sea lions affected with carcinoma were measured in the males. Blubber thickness was significantly different between the two groups of sea lions, but after controlling for this difference, there was still a significant effect of PCBs, but not DDTs, on the probability of sea lions dying with carcinoma. Age, sex, mass and length did not affect the probability of dying from carcinoma.

KW - California sea lions

KW - Carcinoma

KW - Marine mammals

KW - Organochlorines

UR - http://www.scopus.com/inward/record.url?scp=19944433795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19944433795&partnerID=8YFLogxK

U2 - 10.1016/j.marpolbul.2004.08.005

DO - 10.1016/j.marpolbul.2004.08.005

M3 - Article

C2 - 15664031

AN - SCOPUS:19944433795

VL - 50

SP - 30

EP - 39

JO - Marine Pollution Bulletin

JF - Marine Pollution Bulletin

SN - 0025-326X

IS - 1

ER -