The role of organochlorines in cancer-associated mortality in California sea lions (Zalophus californianus)

Gina M. Ylitalo, John E. Stein, Tom Hom, Lyndal L. Johnson, Karen L. Tilbury, Ailsa J. Hall, Teri Rowles, Denise Greig, Linda J Lowenstine, Frances M D Gulland

Research output: Contribution to journalArticlepeer-review

108 Scopus citations

Abstract

Wild California sea lions (Zalophus californianus) have an unusually high prevalence of neoplasms (18% of stranded dead adults) and high levels of contaminants. The contribution of organochlorine (OC) tissue burdens to the probability of sea lions dying from carcinoma was explored using a logistic regression model. Levels of PCBs and DDTs were determined in blubber of sea lions diagnosed with metastatic carcinoma and animals that had died from non-carcinoma-related incidents (e.g., gunshot, domoic acid poisoning). Animals with carcinoma had higher mean concentrations (based on wet weight) of PCBs and DDTs (more than 85% and 30% higher, respectively) in blubber than did sea lions without carcinoma; the highest concentrations of OCs in the sea lions affected with carcinoma were measured in the males. Blubber thickness was significantly different between the two groups of sea lions, but after controlling for this difference, there was still a significant effect of PCBs, but not DDTs, on the probability of sea lions dying with carcinoma. Age, sex, mass and length did not affect the probability of dying from carcinoma.

Original languageEnglish (US)
Pages (from-to)30-39
Number of pages10
JournalMarine Pollution Bulletin
Volume50
Issue number1
DOIs
StatePublished - Jan 2005

Keywords

  • California sea lions
  • Carcinoma
  • Marine mammals
  • Organochlorines

ASJC Scopus subject areas

  • Aquatic Science
  • Oceanography
  • Pollution

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