The role of nitric oxide in mediating tumour blood flow

George Van Buren, E. Ramsay Camp, Anthony D. Yang, Michael J. Gray, Fan Fan, Ray Somcio, Lee M. Ellis

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Nitric oxide (NO) is a ubiquitous molecule with a myriad of physiological and pathophysiological roles. It has numerous direct and indirect effects on tumour vasculature as both a regulatory and effector molecule. NO affects tumour blood flow through its effects on tumour angiogenesis, vascular tone and vascular permeability, partly via its interaction with vascular endothelial growth factor. In this review, the authors examine the basic tenants of NO biology, the association of NO with tumour progression, and the role NO plays in mediating alterations in vascular functions in tumours.

Original languageEnglish (US)
Pages (from-to)689-701
Number of pages13
JournalExpert Opinion on Therapeutic Targets
Volume10
Issue number5
DOIs
StatePublished - Oct 2006
Externally publishedYes

Fingerprint

Tumors
Nitric Oxide
Blood
Neoplasms
Blood Vessels
Molecules
Capillary Permeability
Vascular Endothelial Growth Factor A

Keywords

  • Angiogenesis
  • Blood flow
  • Nitric oxide
  • Pericyte

ASJC Scopus subject areas

  • Molecular Medicine
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Van Buren, G., Camp, E. R., Yang, A. D., Gray, M. J., Fan, F., Somcio, R., & Ellis, L. M. (2006). The role of nitric oxide in mediating tumour blood flow. Expert Opinion on Therapeutic Targets, 10(5), 689-701. https://doi.org/10.1517/14728222.10.5.689

The role of nitric oxide in mediating tumour blood flow. / Van Buren, George; Camp, E. Ramsay; Yang, Anthony D.; Gray, Michael J.; Fan, Fan; Somcio, Ray; Ellis, Lee M.

In: Expert Opinion on Therapeutic Targets, Vol. 10, No. 5, 10.2006, p. 689-701.

Research output: Contribution to journalArticle

Van Buren, G, Camp, ER, Yang, AD, Gray, MJ, Fan, F, Somcio, R & Ellis, LM 2006, 'The role of nitric oxide in mediating tumour blood flow', Expert Opinion on Therapeutic Targets, vol. 10, no. 5, pp. 689-701. https://doi.org/10.1517/14728222.10.5.689
Van Buren G, Camp ER, Yang AD, Gray MJ, Fan F, Somcio R et al. The role of nitric oxide in mediating tumour blood flow. Expert Opinion on Therapeutic Targets. 2006 Oct;10(5):689-701. https://doi.org/10.1517/14728222.10.5.689
Van Buren, George ; Camp, E. Ramsay ; Yang, Anthony D. ; Gray, Michael J. ; Fan, Fan ; Somcio, Ray ; Ellis, Lee M. / The role of nitric oxide in mediating tumour blood flow. In: Expert Opinion on Therapeutic Targets. 2006 ; Vol. 10, No. 5. pp. 689-701.
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