The Role of Lipids and Lipid Metabolism in Age-Related Macular Degeneration

Bobeck S. Modjtahedi; Amar U. Kishan; Shilpa Mathew; Lawrence S Morse

doi:10.1016/B978-0-12-401717-7.00007-1

The Role of Lipids and Lipid Metabolism in Age-Related Macular Degeneration

Bobeck S. Modjtahedi, Amar U. Kishan, Shilpa Mathew, Lawrence S Morse

Ophthalmology and Vision Science

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Age-related macular degeneration (AMD) constitutes a major cause of visual morbidity. Efforts have been extended to determine the mechanisms underlying AMD pathogenesis and to develop treatments and preventive measures. This chapter reviews the relevant literature on the role of lipids and lipid metabolism on the pathogenesis of AMD with a focus on both animal and human studies. Dietary omega-3 fatty acid and the role of lipoproteins in the eye are particularly emphasized. However, though evidence suggests possible benefits to higher intake of omega-3 fatty acids in the prevention of AMD, these recommendations have yet to be fully vetted with properly developed double-blind, randomized control trials.

Original language	English (US)
Title of host publication	Handbook of Nutrition, Diet and the Eye
Publisher	Elsevier Inc.
Pages	65-76
Number of pages	12
ISBN (Print)	9780124046061, 9780124017177
DOIs	https://doi.org/10.1016/B978-0-12-401717-7.00007-1
State	Published - Apr 10 2014

Keywords

Age-related macular degeneration
Cholesterol
Diet
Docosahexaenoic acid
Human
Inflammation
Lipids
Metabolism
Omega-3
Statin

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1016/B978-0-12-401717-7.00007-1

Fingerprint Dive into the research topics of 'The Role of Lipids and Lipid Metabolism in Age-Related Macular Degeneration'. Together they form a unique fingerprint.

Cite this

@inbook{2cbb1d233bfb401598aa43d48b0fbfd1,

title = "The Role of Lipids and Lipid Metabolism in Age-Related Macular Degeneration",

abstract = "Age-related macular degeneration (AMD) constitutes a major cause of visual morbidity. Efforts have been extended to determine the mechanisms underlying AMD pathogenesis and to develop treatments and preventive measures. This chapter reviews the relevant literature on the role of lipids and lipid metabolism on the pathogenesis of AMD with a focus on both animal and human studies. Dietary omega-3 fatty acid and the role of lipoproteins in the eye are particularly emphasized. However, though evidence suggests possible benefits to higher intake of omega-3 fatty acids in the prevention of AMD, these recommendations have yet to be fully vetted with properly developed double-blind, randomized control trials.",

keywords = "Age-related macular degeneration, Cholesterol, Diet, Docosahexaenoic acid, Human, Inflammation, Lipids, Metabolism, Omega-3, Statin",

author = "Modjtahedi, {Bobeck S.} and Kishan, {Amar U.} and Shilpa Mathew and Morse, {Lawrence S}",

year = "2014",

month = apr,

day = "10",

doi = "10.1016/B978-0-12-401717-7.00007-1",

language = "English (US)",

isbn = "9780124046061",

pages = "65--76",

booktitle = "Handbook of Nutrition, Diet and the Eye",

publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - The Role of Lipids and Lipid Metabolism in Age-Related Macular Degeneration

AU - Modjtahedi, Bobeck S.

AU - Kishan, Amar U.

AU - Mathew, Shilpa

AU - Morse, Lawrence S

PY - 2014/4/10

Y1 - 2014/4/10

N2 - Age-related macular degeneration (AMD) constitutes a major cause of visual morbidity. Efforts have been extended to determine the mechanisms underlying AMD pathogenesis and to develop treatments and preventive measures. This chapter reviews the relevant literature on the role of lipids and lipid metabolism on the pathogenesis of AMD with a focus on both animal and human studies. Dietary omega-3 fatty acid and the role of lipoproteins in the eye are particularly emphasized. However, though evidence suggests possible benefits to higher intake of omega-3 fatty acids in the prevention of AMD, these recommendations have yet to be fully vetted with properly developed double-blind, randomized control trials.

AB - Age-related macular degeneration (AMD) constitutes a major cause of visual morbidity. Efforts have been extended to determine the mechanisms underlying AMD pathogenesis and to develop treatments and preventive measures. This chapter reviews the relevant literature on the role of lipids and lipid metabolism on the pathogenesis of AMD with a focus on both animal and human studies. Dietary omega-3 fatty acid and the role of lipoproteins in the eye are particularly emphasized. However, though evidence suggests possible benefits to higher intake of omega-3 fatty acids in the prevention of AMD, these recommendations have yet to be fully vetted with properly developed double-blind, randomized control trials.

KW - Age-related macular degeneration

KW - Cholesterol

KW - Diet

KW - Docosahexaenoic acid

KW - Human

KW - Inflammation

KW - Lipids

KW - Metabolism

KW - Omega-3

KW - Statin

UR - http://www.scopus.com/inward/record.url?scp=84943275697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943275697&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-401717-7.00007-1

DO - 10.1016/B978-0-12-401717-7.00007-1

M3 - Chapter

AN - SCOPUS:84943275697

SN - 9780124046061

SN - 9780124017177

SP - 65

EP - 76

BT - Handbook of Nutrition, Diet and the Eye

PB - Elsevier Inc.

ER -