Abstract
Age-related macular degeneration (AMD) constitutes a major cause of visual morbidity. Efforts have been extended to determine the mechanisms underlying AMD pathogenesis and to develop treatments and preventive measures. This chapter reviews the relevant literature on the role of lipids and lipid metabolism on the pathogenesis of AMD with a focus on both animal and human studies. Dietary omega-3 fatty acid and the role of lipoproteins in the eye are particularly emphasized. However, though evidence suggests possible benefits to higher intake of omega-3 fatty acids in the prevention of AMD, these recommendations have yet to be fully vetted with properly developed double-blind, randomized control trials.
Original language | English (US) |
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Title of host publication | Handbook of Nutrition, Diet and the Eye |
Publisher | Elsevier Inc. |
Pages | 65-76 |
Number of pages | 12 |
ISBN (Print) | 9780124046061, 9780124017177 |
DOIs | |
State | Published - Apr 10 2014 |
Keywords
- Age-related macular degeneration
- Cholesterol
- Diet
- Docosahexaenoic acid
- Human
- Inflammation
- Lipids
- Metabolism
- Omega-3
- Statin
ASJC Scopus subject areas
- Medicine(all)