The Role of Lipids and Lipid Metabolism in Age-Related Macular Degeneration

Bobeck S. Modjtahedi, Amar U. Kishan, Shilpa Mathew, Lawrence S Morse

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Age-related macular degeneration (AMD) constitutes a major cause of visual morbidity. Efforts have been extended to determine the mechanisms underlying AMD pathogenesis and to develop treatments and preventive measures. This chapter reviews the relevant literature on the role of lipids and lipid metabolism on the pathogenesis of AMD with a focus on both animal and human studies. Dietary omega-3 fatty acid and the role of lipoproteins in the eye are particularly emphasized. However, though evidence suggests possible benefits to higher intake of omega-3 fatty acids in the prevention of AMD, these recommendations have yet to be fully vetted with properly developed double-blind, randomized control trials.

Original languageEnglish (US)
Title of host publicationHandbook of Nutrition, Diet and the Eye
PublisherElsevier Inc.
Pages65-76
Number of pages12
ISBN (Print)9780124046061, 9780124017177
DOIs
StatePublished - Apr 10 2014

Keywords

  • Age-related macular degeneration
  • Cholesterol
  • Diet
  • Docosahexaenoic acid
  • Human
  • Inflammation
  • Lipids
  • Metabolism
  • Omega-3
  • Statin

ASJC Scopus subject areas

  • Medicine(all)

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    Modjtahedi, B. S., Kishan, A. U., Mathew, S., & Morse, L. S. (2014). The Role of Lipids and Lipid Metabolism in Age-Related Macular Degeneration. In Handbook of Nutrition, Diet and the Eye (pp. 65-76). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-401717-7.00007-1