The role of iron in T cell development and autoimmunity

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Iron is a vital metal for the proliferation of all cells including those of the immune system. Iron deficiency causes several defects in both the humoral and cellular arms of immunity. One of the most profound changes is a reduction in peripheral T cells and atrophy of the thymus. The presence of transferrin receptor on immature, proliferating thymocytes and the inhibition of thymocyte proliferation and differentiation by anti-transferrin receptor antibody highlight the importance of iron to T cell development. Growing evidence suggests that T cells may in turn, regulate iron metabolism perhaps through interactions with the non-classical major histocompatibility complex gene HFE. The association of the iron transporter NRAMP1 with several autoimmune disorders along with evidence that iron can catalyze the production of cryptic epitopes of several autoantigens, establishes a potential role for iron in the development of autoimmunity.

Original languageEnglish (US)
Pages (from-to)73-78
Number of pages6
JournalAutoimmunity Reviews
Volume2
Issue number2
DOIs
StatePublished - Mar 2003

Fingerprint

Autoimmunity
Iron
T-Lymphocytes
Transferrin Receptors
Thymocytes
Autoantigens
Major Histocompatibility Complex
Cellular Immunity
Thymus Gland
Atrophy
Epitopes
Immune System
Metals
Cell Proliferation
Antibodies
Genes

Keywords

  • HFE
  • Iron
  • NRAMP1
  • Thymus

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The role of iron in T cell development and autoimmunity. / Bowlus, Christopher.

In: Autoimmunity Reviews, Vol. 2, No. 2, 03.2003, p. 73-78.

Research output: Contribution to journalArticle

@article{d086d7b283574d1a81ac42a3b2d758df,
title = "The role of iron in T cell development and autoimmunity",
abstract = "Iron is a vital metal for the proliferation of all cells including those of the immune system. Iron deficiency causes several defects in both the humoral and cellular arms of immunity. One of the most profound changes is a reduction in peripheral T cells and atrophy of the thymus. The presence of transferrin receptor on immature, proliferating thymocytes and the inhibition of thymocyte proliferation and differentiation by anti-transferrin receptor antibody highlight the importance of iron to T cell development. Growing evidence suggests that T cells may in turn, regulate iron metabolism perhaps through interactions with the non-classical major histocompatibility complex gene HFE. The association of the iron transporter NRAMP1 with several autoimmune disorders along with evidence that iron can catalyze the production of cryptic epitopes of several autoantigens, establishes a potential role for iron in the development of autoimmunity.",
keywords = "HFE, Iron, NRAMP1, Thymus",
author = "Christopher Bowlus",
year = "2003",
month = "3",
doi = "10.1016/S1568-9972(02)00143-X",
language = "English (US)",
volume = "2",
pages = "73--78",
journal = "Autoimmunity Reviews",
issn = "1568-9972",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - The role of iron in T cell development and autoimmunity

AU - Bowlus, Christopher

PY - 2003/3

Y1 - 2003/3

N2 - Iron is a vital metal for the proliferation of all cells including those of the immune system. Iron deficiency causes several defects in both the humoral and cellular arms of immunity. One of the most profound changes is a reduction in peripheral T cells and atrophy of the thymus. The presence of transferrin receptor on immature, proliferating thymocytes and the inhibition of thymocyte proliferation and differentiation by anti-transferrin receptor antibody highlight the importance of iron to T cell development. Growing evidence suggests that T cells may in turn, regulate iron metabolism perhaps through interactions with the non-classical major histocompatibility complex gene HFE. The association of the iron transporter NRAMP1 with several autoimmune disorders along with evidence that iron can catalyze the production of cryptic epitopes of several autoantigens, establishes a potential role for iron in the development of autoimmunity.

AB - Iron is a vital metal for the proliferation of all cells including those of the immune system. Iron deficiency causes several defects in both the humoral and cellular arms of immunity. One of the most profound changes is a reduction in peripheral T cells and atrophy of the thymus. The presence of transferrin receptor on immature, proliferating thymocytes and the inhibition of thymocyte proliferation and differentiation by anti-transferrin receptor antibody highlight the importance of iron to T cell development. Growing evidence suggests that T cells may in turn, regulate iron metabolism perhaps through interactions with the non-classical major histocompatibility complex gene HFE. The association of the iron transporter NRAMP1 with several autoimmune disorders along with evidence that iron can catalyze the production of cryptic epitopes of several autoantigens, establishes a potential role for iron in the development of autoimmunity.

KW - HFE

KW - Iron

KW - NRAMP1

KW - Thymus

UR - http://www.scopus.com/inward/record.url?scp=0141957994&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141957994&partnerID=8YFLogxK

U2 - 10.1016/S1568-9972(02)00143-X

DO - 10.1016/S1568-9972(02)00143-X

M3 - Article

C2 - 12848962

AN - SCOPUS:0141957994

VL - 2

SP - 73

EP - 78

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

SN - 1568-9972

IS - 2

ER -