TY - JOUR
T1 - The role of hypothalamus-pituitary-adrenal (HPA)-like axis in inflammatory pilosebaceous disorders
AU - Saric-Bosanac, Suzana
AU - Clark, Ashley K.
AU - Sivamani, Raja K.
AU - Shi, Vivian Y.
PY - 2020/2/15
Y1 - 2020/2/15
N2 - Skin is the largest peripheral endocrine organ and functions as a hormone target and endocrine gland. A cutaneous hypothalamus-pituitary-adrenal (HPA)-like axis enables the skin to respond to stress and regulates its steroidogenic activity. The pilosebaceous unit is a site for production and metabolism of a number of steroid hormones, including stress and sex hormones. This is an overview of the important role that the cutaneous HPA-like-axis plays in the pathogenesis and treatment of inflammatory pilosebaceous disorders, including acne, rosacea, seborrheic dermatitis, and hidradenitis suppurativa.
AB - Skin is the largest peripheral endocrine organ and functions as a hormone target and endocrine gland. A cutaneous hypothalamus-pituitary-adrenal (HPA)-like axis enables the skin to respond to stress and regulates its steroidogenic activity. The pilosebaceous unit is a site for production and metabolism of a number of steroid hormones, including stress and sex hormones. This is an overview of the important role that the cutaneous HPA-like-axis plays in the pathogenesis and treatment of inflammatory pilosebaceous disorders, including acne, rosacea, seborrheic dermatitis, and hidradenitis suppurativa.
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M3 - Review article
C2 - 32239884
AN - SCOPUS:85082980238
VL - 26
JO - Dermatology Online Journal
JF - Dermatology Online Journal
SN - 1087-2108
IS - 2
ER -