The role of hypothalamus-pituitary-adrenal (HPA)-like axis in inflammatory pilosebaceous disorders

Suzana Saric-Bosanac, Ashley K. Clark, Raja K. Sivamani, Vivian Y. Shi

Research output: Contribution to journalReview article

Abstract

Skin is the largest peripheral endocrine organ and functions as a hormone target and endocrine gland. A cutaneous hypothalamus-pituitary-adrenal (HPA)-like axis enables the skin to respond to stress and regulates its steroidogenic activity. The pilosebaceous unit is a site for production and metabolism of a number of steroid hormones, including stress and sex hormones. This is an overview of the important role that the cutaneous HPA-like-axis plays in the pathogenesis and treatment of inflammatory pilosebaceous disorders, including acne, rosacea, seborrheic dermatitis, and hidradenitis suppurativa.

Original languageEnglish (US)
JournalDermatology online journal
Volume26
Issue number2
StatePublished - Feb 15 2020

ASJC Scopus subject areas

  • Dermatology

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