The role of herpes simplex virus type 2 and other genital infections in the acquisition of HIV-1 among high-risk women in northern Tanzania

Saidi H. Kapiga, Noel E. Sam, Heejung Bang, Quanhoong Ni, Trong T H Ao, Ireen Kiwelu, Sarah Chiduo, Uzodinma Ndibe, George Seage, Paul Coplan, John Shao, Zeda F. Rosenberg, Max Essex

Research output: Contribution to journalArticle

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Abstract

Background. We examined the role of herpes simplex virus type 2 (HSV-2) and other genital infections on human immunodeficiency virus type 1 (HIV-1) incidence in a cohort study conducted between 2002 and 2005 among female bar/hotel workers in Moshi, Tanzania. Methods. At baseline and every 3 months thereafter, participants were interviewed, and blood and genital samples were collected. Predictors of HIV-1 incidence were evaluated using a Cox proportional hazards regression model. Results. Of 845 women who were HIV-1 seronegative at baseline, 689 (81.5%) were monitored in the study for a total of 698.6 person-years at risk (PYARs). The overall HIV-1 incidence was 4.6/100 PYARs (95% confidence interval [CI], 3.0-6.2/100 PYARs), and condom use was very low. After adjustment for other risk factors, the risk of HIV-1 was increased among women with HSV-2 at baseline (hazard ratio [HR], 4.3 [95% CI, 1.5-12.4]) and in those who acquired HSV-2 during the study period (HR, 5.5 [95% CI, 1.2-25.4]). Other independent predictors of HIV-1 were baseline chlamydial infection (HR, 5.2), bacterial vaginosis (HR, 2.1), and the occurrence of genital ulcers (HR, 2.7). Conclusion. HSV-2 and other genital infections were the most important risk factors for HIV-1. Control of these infections could help to reduce HIV-1 incidence in this population.

Original languageEnglish (US)
Pages (from-to)1260-1269
Number of pages10
JournalJournal of Infectious Diseases
Volume195
Issue number9
DOIs
StatePublished - May 1 2007
Externally publishedYes

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Human Herpesvirus 2
Tanzania
HIV-1
Infection
Incidence
Confidence Intervals
Bacterial Vaginosis
Condoms
Infection Control
Proportional Hazards Models
Ulcer
Cohort Studies

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

The role of herpes simplex virus type 2 and other genital infections in the acquisition of HIV-1 among high-risk women in northern Tanzania. / Kapiga, Saidi H.; Sam, Noel E.; Bang, Heejung; Ni, Quanhoong; Ao, Trong T H; Kiwelu, Ireen; Chiduo, Sarah; Ndibe, Uzodinma; Seage, George; Coplan, Paul; Shao, John; Rosenberg, Zeda F.; Essex, Max.

In: Journal of Infectious Diseases, Vol. 195, No. 9, 01.05.2007, p. 1260-1269.

Research output: Contribution to journalArticle

Kapiga, SH, Sam, NE, Bang, H, Ni, Q, Ao, TTH, Kiwelu, I, Chiduo, S, Ndibe, U, Seage, G, Coplan, P, Shao, J, Rosenberg, ZF & Essex, M 2007, 'The role of herpes simplex virus type 2 and other genital infections in the acquisition of HIV-1 among high-risk women in northern Tanzania', Journal of Infectious Diseases, vol. 195, no. 9, pp. 1260-1269. https://doi.org/10.1086/513566
Kapiga, Saidi H. ; Sam, Noel E. ; Bang, Heejung ; Ni, Quanhoong ; Ao, Trong T H ; Kiwelu, Ireen ; Chiduo, Sarah ; Ndibe, Uzodinma ; Seage, George ; Coplan, Paul ; Shao, John ; Rosenberg, Zeda F. ; Essex, Max. / The role of herpes simplex virus type 2 and other genital infections in the acquisition of HIV-1 among high-risk women in northern Tanzania. In: Journal of Infectious Diseases. 2007 ; Vol. 195, No. 9. pp. 1260-1269.
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abstract = "Background. We examined the role of herpes simplex virus type 2 (HSV-2) and other genital infections on human immunodeficiency virus type 1 (HIV-1) incidence in a cohort study conducted between 2002 and 2005 among female bar/hotel workers in Moshi, Tanzania. Methods. At baseline and every 3 months thereafter, participants were interviewed, and blood and genital samples were collected. Predictors of HIV-1 incidence were evaluated using a Cox proportional hazards regression model. Results. Of 845 women who were HIV-1 seronegative at baseline, 689 (81.5{\%}) were monitored in the study for a total of 698.6 person-years at risk (PYARs). The overall HIV-1 incidence was 4.6/100 PYARs (95{\%} confidence interval [CI], 3.0-6.2/100 PYARs), and condom use was very low. After adjustment for other risk factors, the risk of HIV-1 was increased among women with HSV-2 at baseline (hazard ratio [HR], 4.3 [95{\%} CI, 1.5-12.4]) and in those who acquired HSV-2 during the study period (HR, 5.5 [95{\%} CI, 1.2-25.4]). Other independent predictors of HIV-1 were baseline chlamydial infection (HR, 5.2), bacterial vaginosis (HR, 2.1), and the occurrence of genital ulcers (HR, 2.7). Conclusion. HSV-2 and other genital infections were the most important risk factors for HIV-1. Control of these infections could help to reduce HIV-1 incidence in this population.",
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T1 - The role of herpes simplex virus type 2 and other genital infections in the acquisition of HIV-1 among high-risk women in northern Tanzania

AU - Kapiga, Saidi H.

AU - Sam, Noel E.

AU - Bang, Heejung

AU - Ni, Quanhoong

AU - Ao, Trong T H

AU - Kiwelu, Ireen

AU - Chiduo, Sarah

AU - Ndibe, Uzodinma

AU - Seage, George

AU - Coplan, Paul

AU - Shao, John

AU - Rosenberg, Zeda F.

AU - Essex, Max

PY - 2007/5/1

Y1 - 2007/5/1

N2 - Background. We examined the role of herpes simplex virus type 2 (HSV-2) and other genital infections on human immunodeficiency virus type 1 (HIV-1) incidence in a cohort study conducted between 2002 and 2005 among female bar/hotel workers in Moshi, Tanzania. Methods. At baseline and every 3 months thereafter, participants were interviewed, and blood and genital samples were collected. Predictors of HIV-1 incidence were evaluated using a Cox proportional hazards regression model. Results. Of 845 women who were HIV-1 seronegative at baseline, 689 (81.5%) were monitored in the study for a total of 698.6 person-years at risk (PYARs). The overall HIV-1 incidence was 4.6/100 PYARs (95% confidence interval [CI], 3.0-6.2/100 PYARs), and condom use was very low. After adjustment for other risk factors, the risk of HIV-1 was increased among women with HSV-2 at baseline (hazard ratio [HR], 4.3 [95% CI, 1.5-12.4]) and in those who acquired HSV-2 during the study period (HR, 5.5 [95% CI, 1.2-25.4]). Other independent predictors of HIV-1 were baseline chlamydial infection (HR, 5.2), bacterial vaginosis (HR, 2.1), and the occurrence of genital ulcers (HR, 2.7). Conclusion. HSV-2 and other genital infections were the most important risk factors for HIV-1. Control of these infections could help to reduce HIV-1 incidence in this population.

AB - Background. We examined the role of herpes simplex virus type 2 (HSV-2) and other genital infections on human immunodeficiency virus type 1 (HIV-1) incidence in a cohort study conducted between 2002 and 2005 among female bar/hotel workers in Moshi, Tanzania. Methods. At baseline and every 3 months thereafter, participants were interviewed, and blood and genital samples were collected. Predictors of HIV-1 incidence were evaluated using a Cox proportional hazards regression model. Results. Of 845 women who were HIV-1 seronegative at baseline, 689 (81.5%) were monitored in the study for a total of 698.6 person-years at risk (PYARs). The overall HIV-1 incidence was 4.6/100 PYARs (95% confidence interval [CI], 3.0-6.2/100 PYARs), and condom use was very low. After adjustment for other risk factors, the risk of HIV-1 was increased among women with HSV-2 at baseline (hazard ratio [HR], 4.3 [95% CI, 1.5-12.4]) and in those who acquired HSV-2 during the study period (HR, 5.5 [95% CI, 1.2-25.4]). Other independent predictors of HIV-1 were baseline chlamydial infection (HR, 5.2), bacterial vaginosis (HR, 2.1), and the occurrence of genital ulcers (HR, 2.7). Conclusion. HSV-2 and other genital infections were the most important risk factors for HIV-1. Control of these infections could help to reduce HIV-1 incidence in this population.

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DO - 10.1086/513566

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