The role of herpes simplex virus type 2 and other genital infections in the acquisition of HIV-1 among high-risk women in northern Tanzania

Saidi H. Kapiga, Noel E. Sam, Heejung Bang, Quanhoong Ni, Trong T H Ao, Ireen Kiwelu, Sarah Chiduo, Uzodinma Ndibe, George Seage, Paul Coplan, John Shao, Zeda F. Rosenberg, Max Essex

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Background. We examined the role of herpes simplex virus type 2 (HSV-2) and other genital infections on human immunodeficiency virus type 1 (HIV-1) incidence in a cohort study conducted between 2002 and 2005 among female bar/hotel workers in Moshi, Tanzania. Methods. At baseline and every 3 months thereafter, participants were interviewed, and blood and genital samples were collected. Predictors of HIV-1 incidence were evaluated using a Cox proportional hazards regression model. Results. Of 845 women who were HIV-1 seronegative at baseline, 689 (81.5%) were monitored in the study for a total of 698.6 person-years at risk (PYARs). The overall HIV-1 incidence was 4.6/100 PYARs (95% confidence interval [CI], 3.0-6.2/100 PYARs), and condom use was very low. After adjustment for other risk factors, the risk of HIV-1 was increased among women with HSV-2 at baseline (hazard ratio [HR], 4.3 [95% CI, 1.5-12.4]) and in those who acquired HSV-2 during the study period (HR, 5.5 [95% CI, 1.2-25.4]). Other independent predictors of HIV-1 were baseline chlamydial infection (HR, 5.2), bacterial vaginosis (HR, 2.1), and the occurrence of genital ulcers (HR, 2.7). Conclusion. HSV-2 and other genital infections were the most important risk factors for HIV-1. Control of these infections could help to reduce HIV-1 incidence in this population.

Original languageEnglish (US)
Pages (from-to)1260-1269
Number of pages10
JournalJournal of Infectious Diseases
Volume195
Issue number9
DOIs
StatePublished - May 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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    Kapiga, S. H., Sam, N. E., Bang, H., Ni, Q., Ao, T. T. H., Kiwelu, I., Chiduo, S., Ndibe, U., Seage, G., Coplan, P., Shao, J., Rosenberg, Z. F., & Essex, M. (2007). The role of herpes simplex virus type 2 and other genital infections in the acquisition of HIV-1 among high-risk women in northern Tanzania. Journal of Infectious Diseases, 195(9), 1260-1269. https://doi.org/10.1086/513566