The role of genome diversity and immune evasion in persistent infection with Helicobacter pylori

Cara L. Cooke, Jennifer L. Huff, Jay V Solnick

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Helicobacter pylori is an important human pathogen that chronically colonizes the stomach of half the world's population. Infection typically occurs in childhood and persists for decades, if not for the lifetime of the host. How is bacterial persistence possible despite a vigorous innate and adaptive immune response? Here we describe the complex role of bacterial diversity and specific mechanisms to avoid or subvert host immunity in bacterial persistence. We suggest that H. pylori finely modulates the extent to which it interacts with the host in order to promote chronic infection, and that it uses diverse mechanisms to do so.

Original languageEnglish (US)
Pages (from-to)11-23
Number of pages13
JournalFEMS Immunology and Medical Microbiology
Volume45
Issue number1
DOIs
StatePublished - Jul 1 2005

Keywords

  • Genome diversity
  • Helicobacter pylori
  • Immune evasion

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Infectious Diseases

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