The role of Galectin-3 in stellate cell activation and liver fibrosis

Xiaosong Jiang, Xiangling Chen, Hiroo Fukada, Dan K. Hsu, Fu-Tong Liu, Natalia J Torok

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Gal3 (galectin-3) has been known to be involved in the regulation of kidney, lung and liver fibrosis. We have reported a novel mechanism by which Gal3 contributes to fibrogenesis. Extracellular Gal3 is required for tethering of apoptotic bodies by HSC via cross-linking with integrin αvβ3, and consequently promoting HSC activation. On the other hand, phagocytosis induces Gal3 production by both HSC and Kupffer cells. Taken together, Gal3 may become a therapeutic target for antifibrogenic strategy.

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Jiang, X., Chen, X., Fukada, H., Hsu, D. K., Liu, F-T., & Torok, N. J. (2012). The role of Galectin-3 in stellate cell activation and liver fibrosis. In ACS Symposium Series (Vol. 1115, pp. 391-395). (ACS Symposium Series; Vol. 1115). American Chemical Society. https://doi.org/10.1021/bk-2012-1115.ch023