The role of Galectin-3 in stellate cell activation and liver fibrosis

Xiaosong Jiang, Xiangling Chen, Hiroo Fukada, Dan K. Hsu, Fu-Tong Liu, Natalia J Torok

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Gal3 (galectin-3) has been known to be involved in the regulation of kidney, lung and liver fibrosis. We have reported a novel mechanism by which Gal3 contributes to fibrogenesis. Extracellular Gal3 is required for tethering of apoptotic bodies by HSC via cross-linking with integrin αvβ3, and consequently promoting HSC activation. On the other hand, phagocytosis induces Gal3 production by both HSC and Kupffer cells. Taken together, Gal3 may become a therapeutic target for antifibrogenic strategy.

Original languageEnglish (US)
Title of host publicationACS Symposium Series
PublisherAmerican Chemical Society
Pages391-395
Number of pages5
Volume1115
ISBN (Print)9780841228801
DOIs
StatePublished - Dec 18 2012

Publication series

NameACS Symposium Series
Volume1115
ISSN (Print)00976156
ISSN (Electronic)19475918

Fingerprint

Galectin 3
Liver
Chemical activation
Integrins
Kupffer Cells

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Jiang, X., Chen, X., Fukada, H., Hsu, D. K., Liu, F-T., & Torok, N. J. (2012). The role of Galectin-3 in stellate cell activation and liver fibrosis. In ACS Symposium Series (Vol. 1115, pp. 391-395). (ACS Symposium Series; Vol. 1115). American Chemical Society. https://doi.org/10.1021/bk-2012-1115.ch023

The role of Galectin-3 in stellate cell activation and liver fibrosis. / Jiang, Xiaosong; Chen, Xiangling; Fukada, Hiroo; Hsu, Dan K.; Liu, Fu-Tong; Torok, Natalia J.

ACS Symposium Series. Vol. 1115 American Chemical Society, 2012. p. 391-395 (ACS Symposium Series; Vol. 1115).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Jiang, X, Chen, X, Fukada, H, Hsu, DK, Liu, F-T & Torok, NJ 2012, The role of Galectin-3 in stellate cell activation and liver fibrosis. in ACS Symposium Series. vol. 1115, ACS Symposium Series, vol. 1115, American Chemical Society, pp. 391-395. https://doi.org/10.1021/bk-2012-1115.ch023
Jiang X, Chen X, Fukada H, Hsu DK, Liu F-T, Torok NJ. The role of Galectin-3 in stellate cell activation and liver fibrosis. In ACS Symposium Series. Vol. 1115. American Chemical Society. 2012. p. 391-395. (ACS Symposium Series). https://doi.org/10.1021/bk-2012-1115.ch023
Jiang, Xiaosong ; Chen, Xiangling ; Fukada, Hiroo ; Hsu, Dan K. ; Liu, Fu-Tong ; Torok, Natalia J. / The role of Galectin-3 in stellate cell activation and liver fibrosis. ACS Symposium Series. Vol. 1115 American Chemical Society, 2012. pp. 391-395 (ACS Symposium Series).
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