The role of Galectin-3 in stellate cell activation and liver fibrosis

Xiaosong Jiang; Xiangling Chen; Hiroo Fukada; Dan K. Hsu; Fu-Tong Liu; Natalia J Torok

doi:10.1021/bk-2012-1115.ch023

The role of Galectin-3 in stellate cell activation and liver fibrosis

Xiaosong Jiang, Xiangling Chen, Hiroo Fukada, Dan K. Hsu, Fu-Tong Liu, Natalia J Torok

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Gal3 (galectin-3) has been known to be involved in the regulation of kidney, lung and liver fibrosis. We have reported a novel mechanism by which Gal3 contributes to fibrogenesis. Extracellular Gal3 is required for tethering of apoptotic bodies by HSC via cross-linking with integrin αvβ3, and consequently promoting HSC activation. On the other hand, phagocytosis induces Gal3 production by both HSC and Kupffer cells. Taken together, Gal3 may become a therapeutic target for antifibrogenic strategy.

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Jiang, X., Chen, X., Fukada, H., Hsu, D. K., Liu, F-T., & Torok, N. J. (2012). The role of Galectin-3 in stellate cell activation and liver fibrosis. In ACS Symposium Series (Vol. 1115, pp. 391-395). (ACS Symposium Series; Vol. 1115). American Chemical Society. https://doi.org/10.1021/bk-2012-1115.ch023

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title = "The role of Galectin-3 in stellate cell activation and liver fibrosis",

abstract = "Gal3 (galectin-3) has been known to be involved in the regulation of kidney, lung and liver fibrosis. We have reported a novel mechanism by which Gal3 contributes to fibrogenesis. Extracellular Gal3 is required for tethering of apoptotic bodies by HSC via cross-linking with integrin αvβ3, and consequently promoting HSC activation. On the other hand, phagocytosis induces Gal3 production by both HSC and Kupffer cells. Taken together, Gal3 may become a therapeutic target for antifibrogenic strategy.",

author = "Xiaosong Jiang and Xiangling Chen and Hiroo Fukada and Hsu, {Dan K.} and Fu-Tong Liu and Torok, {Natalia J}",

year = "2012",

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doi = "10.1021/bk-2012-1115.ch023",

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volume = "1115",

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publisher = "American Chemical Society",

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T1 - The role of Galectin-3 in stellate cell activation and liver fibrosis

AU - Jiang, Xiaosong

AU - Chen, Xiangling

AU - Fukada, Hiroo

AU - Hsu, Dan K.

AU - Liu, Fu-Tong

AU - Torok, Natalia J

PY - 2012/12/18

Y1 - 2012/12/18

N2 - Gal3 (galectin-3) has been known to be involved in the regulation of kidney, lung and liver fibrosis. We have reported a novel mechanism by which Gal3 contributes to fibrogenesis. Extracellular Gal3 is required for tethering of apoptotic bodies by HSC via cross-linking with integrin αvβ3, and consequently promoting HSC activation. On the other hand, phagocytosis induces Gal3 production by both HSC and Kupffer cells. Taken together, Gal3 may become a therapeutic target for antifibrogenic strategy.

AB - Gal3 (galectin-3) has been known to be involved in the regulation of kidney, lung and liver fibrosis. We have reported a novel mechanism by which Gal3 contributes to fibrogenesis. Extracellular Gal3 is required for tethering of apoptotic bodies by HSC via cross-linking with integrin αvβ3, and consequently promoting HSC activation. On the other hand, phagocytosis induces Gal3 production by both HSC and Kupffer cells. Taken together, Gal3 may become a therapeutic target for antifibrogenic strategy.

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U2 - 10.1021/bk-2012-1115.ch023

DO - 10.1021/bk-2012-1115.ch023

M3 - Conference contribution

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VL - 1115

T3 - ACS Symposium Series

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PB - American Chemical Society

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10.1021/bk-2012-1115.ch023