Abstract
Gal3 (galectin-3) has been known to be involved in the regulation of kidney, lung and liver fibrosis. We have reported a novel mechanism by which Gal3 contributes to fibrogenesis. Extracellular Gal3 is required for tethering of apoptotic bodies by HSC via cross-linking with integrin αvβ3, and consequently promoting HSC activation. On the other hand, phagocytosis induces Gal3 production by both HSC and Kupffer cells. Taken together, Gal3 may become a therapeutic target for antifibrogenic strategy.
| Original language | English (US) |
|---|---|
| Title of host publication | ACS Symposium Series |
| Publisher | American Chemical Society |
| Pages | 391-395 |
| Number of pages | 5 |
| Volume | 1115 |
| ISBN (Print) | 9780841228801 |
| DOIs | |
| State | Published - Dec 18 2012 |
Publication series
| Name | ACS Symposium Series |
|---|---|
| Volume | 1115 |
| ISSN (Print) | 00976156 |
| ISSN (Electronic) | 19475918 |
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ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)
Cite this
The role of Galectin-3 in stellate cell activation and liver fibrosis. / Jiang, Xiaosong; Chen, Xiangling; Fukada, Hiroo; Hsu, Dan K.; Liu, Fu-Tong; Torok, Natalia J.
ACS Symposium Series. Vol. 1115 American Chemical Society, 2012. p. 391-395 (ACS Symposium Series; Vol. 1115).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - The role of Galectin-3 in stellate cell activation and liver fibrosis
AU - Jiang, Xiaosong
AU - Chen, Xiangling
AU - Fukada, Hiroo
AU - Hsu, Dan K.
AU - Liu, Fu-Tong
AU - Torok, Natalia J
PY - 2012/12/18
Y1 - 2012/12/18
N2 - Gal3 (galectin-3) has been known to be involved in the regulation of kidney, lung and liver fibrosis. We have reported a novel mechanism by which Gal3 contributes to fibrogenesis. Extracellular Gal3 is required for tethering of apoptotic bodies by HSC via cross-linking with integrin αvβ3, and consequently promoting HSC activation. On the other hand, phagocytosis induces Gal3 production by both HSC and Kupffer cells. Taken together, Gal3 may become a therapeutic target for antifibrogenic strategy.
AB - Gal3 (galectin-3) has been known to be involved in the regulation of kidney, lung and liver fibrosis. We have reported a novel mechanism by which Gal3 contributes to fibrogenesis. Extracellular Gal3 is required for tethering of apoptotic bodies by HSC via cross-linking with integrin αvβ3, and consequently promoting HSC activation. On the other hand, phagocytosis induces Gal3 production by both HSC and Kupffer cells. Taken together, Gal3 may become a therapeutic target for antifibrogenic strategy.
UR - http://www.scopus.com/inward/record.url?scp=84905238280&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905238280&partnerID=8YFLogxK
U2 - 10.1021/bk-2012-1115.ch023
DO - 10.1021/bk-2012-1115.ch023
M3 - Conference contribution
AN - SCOPUS:84905238280
SN - 9780841228801
VL - 1115
T3 - ACS Symposium Series
SP - 391
EP - 395
BT - ACS Symposium Series
PB - American Chemical Society
ER -