The role of Galectin-3 in stellate cell activation and liver fibrosis

Xiaosong Jiang, Xiangling Chen, Hiroo Fukada, Dan K. Hsu, Fu-Tong Liu, Natalia J Torok

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Gal3 (galectin-3) has been known to be involved in the regulation of kidney, lung and liver fibrosis. We have reported a novel mechanism by which Gal3 contributes to fibrogenesis. Extracellular Gal3 is required for tethering of apoptotic bodies by HSC via cross-linking with integrin αvβ3, and consequently promoting HSC activation. On the other hand, phagocytosis induces Gal3 production by both HSC and Kupffer cells. Taken together, Gal3 may become a therapeutic target for antifibrogenic strategy.

Original languageEnglish (US)
Title of host publicationACS Symposium Series
PublisherAmerican Chemical Society
Pages391-395
Number of pages5
Volume1115
ISBN (Print)9780841228801
DOIs
StatePublished - Dec 18 2012

Publication series

NameACS Symposium Series
Volume1115
ISSN (Print)00976156
ISSN (Electronic)19475918

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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