Abstract
Galanin inhibits food consumption in satiated rats. Discovered relatively recently is a 29-amino-acid neuropeptide, not homologous with any other known peptide. Three G-protein-linked galanin receptor subtypes have been cloned. This review summarizes the mechanisms by which exogenously administered galanin may stimulate ingestion, discusses pharmacological and genetic investigations of the role of endogenous galanin on feeding and body weight, and speculates on the therapeutic potential of non-peptide galanin receptor antagonists for the treatment of appetite disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 369-375 |
| Number of pages | 7 |
| Journal | Neuropeptides |
| Volume | 33 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 1999 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
- Clinical Neurology
- Endocrinology, Diabetes and Metabolism
- Cellular and Molecular Neuroscience
- Neuroscience(all)
- Biochemistry
Cite this
The role of galanin in feeding behavior. / Crawley, Jacqueline.
In: Neuropeptides, Vol. 33, No. 5, 10.1999, p. 369-375.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of galanin in feeding behavior
AU - Crawley, Jacqueline
PY - 1999/10
Y1 - 1999/10
N2 - Galanin inhibits food consumption in satiated rats. Discovered relatively recently is a 29-amino-acid neuropeptide, not homologous with any other known peptide. Three G-protein-linked galanin receptor subtypes have been cloned. This review summarizes the mechanisms by which exogenously administered galanin may stimulate ingestion, discusses pharmacological and genetic investigations of the role of endogenous galanin on feeding and body weight, and speculates on the therapeutic potential of non-peptide galanin receptor antagonists for the treatment of appetite disorders.
AB - Galanin inhibits food consumption in satiated rats. Discovered relatively recently is a 29-amino-acid neuropeptide, not homologous with any other known peptide. Three G-protein-linked galanin receptor subtypes have been cloned. This review summarizes the mechanisms by which exogenously administered galanin may stimulate ingestion, discusses pharmacological and genetic investigations of the role of endogenous galanin on feeding and body weight, and speculates on the therapeutic potential of non-peptide galanin receptor antagonists for the treatment of appetite disorders.
UR - http://www.scopus.com/inward/record.url?scp=0032705681&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032705681&partnerID=8YFLogxK
U2 - 10.1054/npep.1999.0049
DO - 10.1054/npep.1999.0049
M3 - Article
C2 - 10657514
AN - SCOPUS:0032705681
VL - 33
SP - 369
EP - 375
JO - Neuropeptides
JF - Neuropeptides
SN - 0143-4179
IS - 5
ER -