Galanin inhibits food consumption in satiated rats. Discovered relatively recently is a 29-amino-acid neuropeptide, not homologous with any other known peptide. Three G-protein-linked galanin receptor subtypes have been cloned. This review summarizes the mechanisms by which exogenously administered galanin may stimulate ingestion, discusses pharmacological and genetic investigations of the role of endogenous galanin on feeding and body weight, and speculates on the therapeutic potential of non-peptide galanin receptor antagonists for the treatment of appetite disorders.
ASJC Scopus subject areas
- Clinical Neurology
- Endocrinology, Diabetes and Metabolism
- Cellular and Molecular Neuroscience