The role of galanin in cholinergically-mediated memory processes

John K. Robinson, Jacqueline Crawley

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

1. Galanin, a 29 amino-acid neuroactive peptide, has been shown to affect diverse processes throughout the nervous system and to coexist with several "classical" neurotransmitters, including norepinephrine, serotonin, and acetylcholine. 2. Galanin coexists with acetylcholine in neurons of the medial septum, diagonal band, and nucleus basalis of Meynert, cells which degenerate during the course of Alzheimer's disease. 3. In the ventral hippocampus, galanin inhibits the release of acetylcholine and inhibits carbachol stimulated phosphatidyl inositol hydrolysis. 4. Galanin impairs choice accuracy in learning and memory paradigms in rats, and is therefore hypothesized to be a contributory factor in the memory and cognitive disabilities found in Alzheimer's patients. 5. Newly developed galanin antagonists, by eliminating putative inhibitory effects of endogenous galanin on cholinergic function, may serve as useful therapies for memory disorders.

Original languageEnglish (US)
Pages (from-to)71-85
Number of pages15
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume17
Issue number1
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • acetylcholine
  • Alzheimer's disease
  • galanin
  • hippocampus
  • memory
  • neuropeptides
  • nucleus basal is of Meynert

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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