The Role of Epigenomics in Aquatic Toxicology

Susanne M. Brander, Adam D. Biales, Richard E Connon

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Over the past decade, the field of molecular biology has rapidly incorporated epigenetic studies to evaluate organism–environment interactions that can result in chronic effects. Such responses arise from early life stage stress, the utilization of genetic information over an individual's life time, and transgenerational inheritance. Knowledge of epigenetic mechanisms provides the potential for a comprehensive evaluation of multigenerational and heritable effects from environmental stressors, such as contaminants. Focused studies have provided a greater understanding of how many responses to environmental stressors are driven by epigenetic modifiers. We discuss the promise of epigenetics and suggest future research directions within the field of aquatic toxicology, with a particular focus on the potential for identifying key heritable marks with consequential impacts at the organism and population levels. Environ Toxicol Chem 2017;36:2565–2573.

Original languageEnglish (US)
Pages (from-to)2565-2573
Number of pages9
JournalEnvironmental Toxicology and Chemistry
Volume36
Issue number10
DOIs
StatePublished - Oct 1 2017

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Keywords

  • Aquatic toxicology
  • Contaminants
  • Ecotoxicogenomics
  • Epigenetics
  • Stressors

ASJC Scopus subject areas

  • Environmental Chemistry
  • Health, Toxicology and Mutagenesis

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