The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers

Michael Safaee, Michael E. Ivan, Michael C. Oh, Taemin Oh, Eli T. Sayegh, Gurvinder Kaur, Matthew Z. Sun, Orin Bloch, Andrew T. Parsa

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

G-protein coupled receptors (GPCRs) are among the most diverse and ubiquitous proteins in all of biology. The epidermal growth factorseven span transmembrane (EGF-TM7) subfamily of adhesion GPCRs is a small subset whose members are mainly expressed on the surface of leukocytes. The EGF domains on the N-terminus add significant size to these receptors and they are considered to be among the largest members of the TM7 family. Although not all of their ligands or downstream targets have been identified, there is evidence implicating the EGF-TM7 family diverse processes such as cell adhesion, migration, inflammation, and autoimmune disease. Recent studies have identified expression of EGF-TM7 family members on human neoplasms including those of the thyroid, stomach, colon, and brain. Their presence on these tissues is not surprising given the ubiquity of GPCRs, but because their functional significance and pathways are not completely understood, they are of tremendous clinical and scientific interest. Current evidence suggests that expression of certain EGF-TM7 receptors is correlated with tumor grade, confers a more invasive phenotype, and increases the likelihood of metastatic disease. In this review, we will discuss the structure, function, and regulation of these receptors. We also describe the expression of these receptors in human cancers and explore their potential mechanistic significance.

Original languageEnglish (US)
Pages (from-to)20-24
Number of pages5
JournalOncology Reviews
Volume8
Issue number1
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Mucins
Epidermal Growth Factor
G-Protein-Coupled Receptors
Hormones
Neoplasms
Cell Adhesion
Autoimmune Diseases
Cell Movement
Stomach
Thyroid Gland
Colon
Leukocytes
Ligands
Inflammation
Phenotype
Brain
Growth
Proteins

Keywords

  • Cancer
  • EGF-TM7
  • EMR2
  • G-protein coupled receptor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Safaee, M., Ivan, M. E., Oh, M. C., Oh, T., Sayegh, E. T., Kaur, G., ... Parsa, A. T. (2014). The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers. Oncology Reviews, 8(1), 20-24. https://doi.org/10.4081/oncol.2014.242

The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers. / Safaee, Michael; Ivan, Michael E.; Oh, Michael C.; Oh, Taemin; Sayegh, Eli T.; Kaur, Gurvinder; Sun, Matthew Z.; Bloch, Orin; Parsa, Andrew T.

In: Oncology Reviews, Vol. 8, No. 1, 2014, p. 20-24.

Research output: Contribution to journalReview article

Safaee, M, Ivan, ME, Oh, MC, Oh, T, Sayegh, ET, Kaur, G, Sun, MZ, Bloch, O & Parsa, AT 2014, 'The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers', Oncology Reviews, vol. 8, no. 1, pp. 20-24. https://doi.org/10.4081/oncol.2014.242
Safaee, Michael ; Ivan, Michael E. ; Oh, Michael C. ; Oh, Taemin ; Sayegh, Eli T. ; Kaur, Gurvinder ; Sun, Matthew Z. ; Bloch, Orin ; Parsa, Andrew T. / The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers. In: Oncology Reviews. 2014 ; Vol. 8, No. 1. pp. 20-24.
@article{8cfc5ffb48c645a190f5ef28d9ce8834,
title = "The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers",
abstract = "G-protein coupled receptors (GPCRs) are among the most diverse and ubiquitous proteins in all of biology. The epidermal growth factorseven span transmembrane (EGF-TM7) subfamily of adhesion GPCRs is a small subset whose members are mainly expressed on the surface of leukocytes. The EGF domains on the N-terminus add significant size to these receptors and they are considered to be among the largest members of the TM7 family. Although not all of their ligands or downstream targets have been identified, there is evidence implicating the EGF-TM7 family diverse processes such as cell adhesion, migration, inflammation, and autoimmune disease. Recent studies have identified expression of EGF-TM7 family members on human neoplasms including those of the thyroid, stomach, colon, and brain. Their presence on these tissues is not surprising given the ubiquity of GPCRs, but because their functional significance and pathways are not completely understood, they are of tremendous clinical and scientific interest. Current evidence suggests that expression of certain EGF-TM7 receptors is correlated with tumor grade, confers a more invasive phenotype, and increases the likelihood of metastatic disease. In this review, we will discuss the structure, function, and regulation of these receptors. We also describe the expression of these receptors in human cancers and explore their potential mechanistic significance.",
keywords = "Cancer, EGF-TM7, EMR2, G-protein coupled receptor",
author = "Michael Safaee and Ivan, {Michael E.} and Oh, {Michael C.} and Taemin Oh and Sayegh, {Eli T.} and Gurvinder Kaur and Sun, {Matthew Z.} and Orin Bloch and Parsa, {Andrew T.}",
year = "2014",
doi = "10.4081/oncol.2014.242",
language = "English (US)",
volume = "8",
pages = "20--24",
journal = "Oncology Reviews",
issn = "1970-5557",
publisher = "PagePress",
number = "1",

}

TY - JOUR

T1 - The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers

AU - Safaee, Michael

AU - Ivan, Michael E.

AU - Oh, Michael C.

AU - Oh, Taemin

AU - Sayegh, Eli T.

AU - Kaur, Gurvinder

AU - Sun, Matthew Z.

AU - Bloch, Orin

AU - Parsa, Andrew T.

PY - 2014

Y1 - 2014

N2 - G-protein coupled receptors (GPCRs) are among the most diverse and ubiquitous proteins in all of biology. The epidermal growth factorseven span transmembrane (EGF-TM7) subfamily of adhesion GPCRs is a small subset whose members are mainly expressed on the surface of leukocytes. The EGF domains on the N-terminus add significant size to these receptors and they are considered to be among the largest members of the TM7 family. Although not all of their ligands or downstream targets have been identified, there is evidence implicating the EGF-TM7 family diverse processes such as cell adhesion, migration, inflammation, and autoimmune disease. Recent studies have identified expression of EGF-TM7 family members on human neoplasms including those of the thyroid, stomach, colon, and brain. Their presence on these tissues is not surprising given the ubiquity of GPCRs, but because their functional significance and pathways are not completely understood, they are of tremendous clinical and scientific interest. Current evidence suggests that expression of certain EGF-TM7 receptors is correlated with tumor grade, confers a more invasive phenotype, and increases the likelihood of metastatic disease. In this review, we will discuss the structure, function, and regulation of these receptors. We also describe the expression of these receptors in human cancers and explore their potential mechanistic significance.

AB - G-protein coupled receptors (GPCRs) are among the most diverse and ubiquitous proteins in all of biology. The epidermal growth factorseven span transmembrane (EGF-TM7) subfamily of adhesion GPCRs is a small subset whose members are mainly expressed on the surface of leukocytes. The EGF domains on the N-terminus add significant size to these receptors and they are considered to be among the largest members of the TM7 family. Although not all of their ligands or downstream targets have been identified, there is evidence implicating the EGF-TM7 family diverse processes such as cell adhesion, migration, inflammation, and autoimmune disease. Recent studies have identified expression of EGF-TM7 family members on human neoplasms including those of the thyroid, stomach, colon, and brain. Their presence on these tissues is not surprising given the ubiquity of GPCRs, but because their functional significance and pathways are not completely understood, they are of tremendous clinical and scientific interest. Current evidence suggests that expression of certain EGF-TM7 receptors is correlated with tumor grade, confers a more invasive phenotype, and increases the likelihood of metastatic disease. In this review, we will discuss the structure, function, and regulation of these receptors. We also describe the expression of these receptors in human cancers and explore their potential mechanistic significance.

KW - Cancer

KW - EGF-TM7

KW - EMR2

KW - G-protein coupled receptor

UR - http://www.scopus.com/inward/record.url?scp=84903837201&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903837201&partnerID=8YFLogxK

U2 - 10.4081/oncol.2014.242

DO - 10.4081/oncol.2014.242

M3 - Review article

AN - SCOPUS:84903837201

VL - 8

SP - 20

EP - 24

JO - Oncology Reviews

JF - Oncology Reviews

SN - 1970-5557

IS - 1

ER -