Abstract
This chapter gives an overview of the role that diffusion tensor MRI (DTI) can play in the study of cognitive decline that is associated with advancing age. A brief overview of biological injury processes that impinge on the aging brain is provided, and their overall effect on the integrity of neural architecture is described. Cognitive decline associated with aging, and white matter connectivity degradation as a biological substrate for that decline, is then described. We then briefly describe the technology of DTI as a means for in vivo, non-invasive interrogation of white matter connectivity, and relate it to FLAIR, a more traditional MRI method for assessing white matter injury. We then survey the existing findings on relationships between aging-associated neuropathological processes and DTI measurements on one hand; and relationships between DTI measurements and late-life cognitive function on the other. We conclude with a summary of current research directions in relation to DTI studies of cognitive aging.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 289-320 |
| Number of pages | 32 |
| Journal | Current Topics in Behavioral Neurosciences |
| Volume | 11 |
| DOIs | |
| State | Published - 2012 |
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ASJC Scopus subject areas
- Medicine(all)
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The role of diffusion tensor imaging in the study of cognitive aging. / Carmichael, Owen; Lockhart, Samuel.
In: Current Topics in Behavioral Neurosciences, Vol. 11, 2012, p. 289-320.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The role of diffusion tensor imaging in the study of cognitive aging
AU - Carmichael, Owen
AU - Lockhart, Samuel
PY - 2012
Y1 - 2012
N2 - This chapter gives an overview of the role that diffusion tensor MRI (DTI) can play in the study of cognitive decline that is associated with advancing age. A brief overview of biological injury processes that impinge on the aging brain is provided, and their overall effect on the integrity of neural architecture is described. Cognitive decline associated with aging, and white matter connectivity degradation as a biological substrate for that decline, is then described. We then briefly describe the technology of DTI as a means for in vivo, non-invasive interrogation of white matter connectivity, and relate it to FLAIR, a more traditional MRI method for assessing white matter injury. We then survey the existing findings on relationships between aging-associated neuropathological processes and DTI measurements on one hand; and relationships between DTI measurements and late-life cognitive function on the other. We conclude with a summary of current research directions in relation to DTI studies of cognitive aging.
AB - This chapter gives an overview of the role that diffusion tensor MRI (DTI) can play in the study of cognitive decline that is associated with advancing age. A brief overview of biological injury processes that impinge on the aging brain is provided, and their overall effect on the integrity of neural architecture is described. Cognitive decline associated with aging, and white matter connectivity degradation as a biological substrate for that decline, is then described. We then briefly describe the technology of DTI as a means for in vivo, non-invasive interrogation of white matter connectivity, and relate it to FLAIR, a more traditional MRI method for assessing white matter injury. We then survey the existing findings on relationships between aging-associated neuropathological processes and DTI measurements on one hand; and relationships between DTI measurements and late-life cognitive function on the other. We conclude with a summary of current research directions in relation to DTI studies of cognitive aging.
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U2 - 10.1007/7854_2011_176
DO - 10.1007/7854_2011_176
M3 - Article
VL - 11
SP - 289
EP - 320
JO - Current Topics in Behavioral Neurosciences
JF - Current Topics in Behavioral Neurosciences
SN - 1866-3370
ER -