The role of dietary supplementation with plant sterols and stanols in the prevention of cardiovascular disease

Sridevi Devaraj, Ishwarlal Jialal

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Several studies have shown that increased levels of low-density lipoprotein (LDL) cholesterol predict cardiovascular events. The Adult Treatment Panel II (ATP II) introduced the principle of therapeutic lifestyle changes, including plant sterols/stanols for the management of LDL cholesterol. Plant sterols and stanols in fat matrices effectively lower LDL cholesterol levels in hypercholesterolemic, diabetic, and healthy human volunteers. Recent studies also show that sterols (2 g/d) lower LDL cholesterol even when incorporated in nonfat matrices. In addition, they may reduce biomarkers of oxidative stress and inflammation. Plant sterols and stanols exert their hypocholesterolemic effects possibly by interfering with the uptake of both dietary and biliary cholesterol from the intestinal tract. Present evidence is accumulating to promote their use for lowering LDL cholesterol levels, as a first line of therapy (as well as adjunctive therapy) in patients on statin therapy.

Original languageEnglish (US)
Pages (from-to)348-354
Number of pages7
JournalNutrition Reviews
Volume64
Issue number7
DOIs
StatePublished - 2006

Fingerprint

plant stanols
Phytosterols
phytosterols
Dietary Supplements
low density lipoprotein cholesterol
LDL Cholesterol
cardiovascular diseases
dietary supplements
Cardiovascular Diseases
therapeutics
Dietary Cholesterol
Therapeutics
Hydroxymethylglutaryl-CoA Reductase Inhibitors
cholesteremic effect
Sterols
sterols
lifestyle
volunteers
Life Style
biomarkers

Keywords

  • LDL cholesterol
  • Lifestyle
  • Stanol
  • Sterol

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

The role of dietary supplementation with plant sterols and stanols in the prevention of cardiovascular disease. / Devaraj, Sridevi; Jialal, Ishwarlal.

In: Nutrition Reviews, Vol. 64, No. 7, 2006, p. 348-354.

Research output: Contribution to journalArticle

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