The role of central and peripheral cholecystokinin in mediating appetitive behaviors

Jacqueline Crawley, J. A. Rojas-Ramirez, W. B. Mendelson

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Cholecystokinin (CCK) reduces total food consumption in mice, rats, pigs, sheep, monkeys and humans. Behaviors associated with an underlying state of satiety are reported after CCK administration. Reductions in exploration and social interactions by CCK are not due to true sedation or sleep, as measured by cortical EEG recordings. The satiety effects appear to be mediated by peripheral CCK receptors, through a feedback loop involving the vagus nerve. The conceptual link between the behavioral functions of CCK as a putative satiety signal and its established digestive functions are discussed.

Original languageEnglish (US)
Pages (from-to)535-538
Number of pages4
Issue number3
StatePublished - 1982
Externally publishedYes


  • Cholecystokinin
  • Exploratory behavior
  • Feeding behavior
  • Sleep
  • Social behavior

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience


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