The role of Apligraf in the treatment of venous leg ulcers.

K. Dolynchuk, P. Hull, L. Guenther, R. G. Sibbald, Alain Brassard, M. Cooling, L. Delorme, W. Gulliver, D. H. Bourassa, V. Ho, B. Kunimoto, T. Overholt, K. Papp, J. Tousignant

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

A cultured, allogeneic, bi-layered human skin equivalent has recently become available to help clinicians manage difficult-to-heal venous ulcers. This skin equivalent has an epidermis and dermis similar to human skin. Its living keratinocytes and fibroblasts are from cultured cell banks derived from human neonatal foreskin. Because the skin equivalent is made up of viable human cells, it cannot be terminally sterilized. Safety concerns, which have been addressed, include the risk of possible transmission of infection, immunogenicity, immunological graft rejection, and tumor formation. However, the maternal blood of the neonatal donor and the master cell banks are screened for infectious agents. Additionally, the human skin equivalent is produced under strict aseptic control, with sterility continuously monitored by the Good Manufacturing Processes. This paper reviews the characteristics of this human skin equivalent and provides practice guidelines.

Original languageEnglish (US)
Pages (from-to)34-43
Number of pages10
JournalOstomy/wound management
Volume45
Issue number1
StatePublished - Jan 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Nursing(all)
  • Gastroenterology

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    Dolynchuk, K., Hull, P., Guenther, L., Sibbald, R. G., Brassard, A., Cooling, M., Delorme, L., Gulliver, W., Bourassa, D. H., Ho, V., Kunimoto, B., Overholt, T., Papp, K., & Tousignant, J. (1999). The role of Apligraf in the treatment of venous leg ulcers. Ostomy/wound management, 45(1), 34-43.