The revised starling principle and its relevance to perioperative fluid management

C. Charles Michel, Kenton P. Arkill, Fitz Roy E. Curry

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

The Starling Principle states that fluid movements between blood and the tissue are determined by differences in hydrostatic and colloid osmotic pressures between plasma inside the microvessels and fluid outside them. While experimental evidence has established the general validity of Starling Principle, difficulties in interpreting it quantitatively became apparent when measurements of interstitial fluid (ISF) hydrostatic and colloid osmotic pressures became possible. The revised interpretation recognizes that since vessel walls are permeable to macromolecules, a static equilibrium resulting from the balance of pressures cannot be achieved. Colloid osmotic pressure differences between plasma and interstitial fluid depend on low levels of filtration in most tissues. Plasma volume is maintained as a steady state with fluid loss by filtration being roughly matched by fluid gains from lymph. These differences in colloid osmotic pressure that determine blood-tissue fluid exchange are those across the ultrafilter in vessels walls, namely, the glycocalyx on the luminal surface of vascular endothelium. These differences are distinct from those between mean values of plasma and interstitial fluid since most macromolecules do not pass through the intact glycocalyx. Unlike transient changes, steady state fluid transport is nonlinear with changes in microvascular pressure. This nonlinearity predicts differing effects of the dilution of plasma protein depending on mean microvascular pressures, with increased transcapillary filtration when pressures are similar to plasma colloid osmotic pressure but negligible filtration at low pressures. Since pulmonary capillary pressures are low, monitoring plasma colloid osmotic pressure during large crystalloid infusions may be useful in averting pulmonary edema.

Original languageEnglish (US)
Title of host publicationPerioperative Fluid Management
PublisherSpringer International Publishing
Pages31-74
Number of pages44
ISBN (Electronic)9783319391410
ISBN (Print)9783319391397
DOIs
StatePublished - Jan 1 2016

Fingerprint

Starlings
Osmotic Pressure
Colloids
Pressure
Extracellular Fluid
Glycocalyx
Plasma Volume
Vascular Endothelium
Lymph
Pulmonary Edema
Microvessels
Blood Proteins
Lung

Keywords

  • Colloid infusion
  • Colloid osmotic pressure
  • Crystalloid infusion
  • Fluid exchange
  • Glycocalyx
  • Hydraulic permeability
  • Microvascular pressure
  • Permeability to macromolecules
  • Permeability to macromolecules
  • Reflection coefficient
  • Starling Principle

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Charles Michel, C., Arkill, K. P., & Curry, F. R. E. (2016). The revised starling principle and its relevance to perioperative fluid management. In Perioperative Fluid Management (pp. 31-74). Springer International Publishing. https://doi.org/10.1007/978-3-319-39141-0_2

The revised starling principle and its relevance to perioperative fluid management. / Charles Michel, C.; Arkill, Kenton P.; Curry, Fitz Roy E.

Perioperative Fluid Management. Springer International Publishing, 2016. p. 31-74.

Research output: Chapter in Book/Report/Conference proceedingChapter

Charles Michel, C, Arkill, KP & Curry, FRE 2016, The revised starling principle and its relevance to perioperative fluid management. in Perioperative Fluid Management. Springer International Publishing, pp. 31-74. https://doi.org/10.1007/978-3-319-39141-0_2
Charles Michel C, Arkill KP, Curry FRE. The revised starling principle and its relevance to perioperative fluid management. In Perioperative Fluid Management. Springer International Publishing. 2016. p. 31-74 https://doi.org/10.1007/978-3-319-39141-0_2
Charles Michel, C. ; Arkill, Kenton P. ; Curry, Fitz Roy E. / The revised starling principle and its relevance to perioperative fluid management. Perioperative Fluid Management. Springer International Publishing, 2016. pp. 31-74
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