Abstract
A 28-year-old woman presented with acute leukemia. Surface antigen analysis showed monoclonal kappa immunoglobulin distribution. Morphology was consistent with either acute lymphoblastic leukemia or acute promyelocytic leukemia, hypogranular variant. This dilemma was resolved by examining the leukemic blasts for immunoglobulin gene rearrangement. None were found, ruling out involvement of the B-cell lineage in this malignancy. Cytogenetic analysis showed a clonal abnormality diagnostic of acute promyelocytic leukemia. Immunoglobulin gene rearrangement in cytogenetics are invaluable in the care of patients with acute leukemia and can resolve ambiguities that result from phenotypic analysis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 372-374 |
| Number of pages | 3 |
| Journal | American Journal of Clinical Pathology |
| Volume | 85 |
| Issue number | 3 |
| State | Published - 1986 |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
The resolution of phenotypic ambiguity in a case of human leukemia using cytogenetics and immunoglobulin gene rearrangement. / Meyers, Frederick J; Miller, C. H.; Lewis, J. P.
In: American Journal of Clinical Pathology, Vol. 85, No. 3, 1986, p. 372-374.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The resolution of phenotypic ambiguity in a case of human leukemia using cytogenetics and immunoglobulin gene rearrangement
AU - Meyers, Frederick J
AU - Miller, C. H.
AU - Lewis, J. P.
PY - 1986
Y1 - 1986
N2 - A 28-year-old woman presented with acute leukemia. Surface antigen analysis showed monoclonal kappa immunoglobulin distribution. Morphology was consistent with either acute lymphoblastic leukemia or acute promyelocytic leukemia, hypogranular variant. This dilemma was resolved by examining the leukemic blasts for immunoglobulin gene rearrangement. None were found, ruling out involvement of the B-cell lineage in this malignancy. Cytogenetic analysis showed a clonal abnormality diagnostic of acute promyelocytic leukemia. Immunoglobulin gene rearrangement in cytogenetics are invaluable in the care of patients with acute leukemia and can resolve ambiguities that result from phenotypic analysis.
AB - A 28-year-old woman presented with acute leukemia. Surface antigen analysis showed monoclonal kappa immunoglobulin distribution. Morphology was consistent with either acute lymphoblastic leukemia or acute promyelocytic leukemia, hypogranular variant. This dilemma was resolved by examining the leukemic blasts for immunoglobulin gene rearrangement. None were found, ruling out involvement of the B-cell lineage in this malignancy. Cytogenetic analysis showed a clonal abnormality diagnostic of acute promyelocytic leukemia. Immunoglobulin gene rearrangement in cytogenetics are invaluable in the care of patients with acute leukemia and can resolve ambiguities that result from phenotypic analysis.
UR - http://www.scopus.com/inward/record.url?scp=0022479564&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022479564&partnerID=8YFLogxK
M3 - Article
VL - 85
SP - 372
EP - 374
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 3
ER -