The resolution of phenotypic ambiguity in a case of human leukemia using cytogenetics and immunoglobulin gene rearrangement

Frederick J Meyers, C. H. Miller, J. P. Lewis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 28-year-old woman presented with acute leukemia. Surface antigen analysis showed monoclonal kappa immunoglobulin distribution. Morphology was consistent with either acute lymphoblastic leukemia or acute promyelocytic leukemia, hypogranular variant. This dilemma was resolved by examining the leukemic blasts for immunoglobulin gene rearrangement. None were found, ruling out involvement of the B-cell lineage in this malignancy. Cytogenetic analysis showed a clonal abnormality diagnostic of acute promyelocytic leukemia. Immunoglobulin gene rearrangement in cytogenetics are invaluable in the care of patients with acute leukemia and can resolve ambiguities that result from phenotypic analysis.

Original languageEnglish (US)
Pages (from-to)372-374
Number of pages3
JournalAmerican Journal of Clinical Pathology
Volume85
Issue number3
StatePublished - 1986

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Immunoglobulin Genes
Acute Promyelocytic Leukemia
Gene Rearrangement
Cytogenetics
Leukemia
Cytogenetic Analysis
Cell Lineage
Surface Antigens
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Immunoglobulins
Patient Care
B-Lymphocytes
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

The resolution of phenotypic ambiguity in a case of human leukemia using cytogenetics and immunoglobulin gene rearrangement. / Meyers, Frederick J; Miller, C. H.; Lewis, J. P.

In: American Journal of Clinical Pathology, Vol. 85, No. 3, 1986, p. 372-374.

Research output: Contribution to journalArticle

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