The resolution of phenotypic ambiguity in a case of human leukemia using cytogenetics and immunoglobulin gene rearrangement

Frederick J Meyers, C. H. Miller, J. P. Lewis

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A 28-year-old woman presented with acute leukemia. Surface antigen analysis showed monoclonal kappa immunoglobulin distribution. Morphology was consistent with either acute lymphoblastic leukemia or acute promyelocytic leukemia, hypogranular variant. This dilemma was resolved by examining the leukemic blasts for immunoglobulin gene rearrangement. None were found, ruling out involvement of the B-cell lineage in this malignancy. Cytogenetic analysis showed a clonal abnormality diagnostic of acute promyelocytic leukemia. Immunoglobulin gene rearrangement in cytogenetics are invaluable in the care of patients with acute leukemia and can resolve ambiguities that result from phenotypic analysis.

Original languageEnglish (US)
Pages (from-to)372-374
Number of pages3
JournalAmerican Journal of Clinical Pathology
Volume85
Issue number3
StatePublished - 1986

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'The resolution of phenotypic ambiguity in a case of human leukemia using cytogenetics and immunoglobulin gene rearrangement'. Together they form a unique fingerprint.

  • Cite this