The renal effects of 7.5% NaCl-6% dextran-70 versus lactated ringer's resuscitation of hemorrhage in dehydrated sheep

Hung S Ho, Jill L. Sondeen, Michael A. Dubick, Charles E. Wade, Robert A. Gunther

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

A small volume of 7.5% NaCl/6% Dextran-70 (HSD) can rapidly expand the plasma volume, but concerns exist regarding its adverse effects on renal function in the dehydrated state. Sheep were thirsted for 4 days (13% plasma volume contraction), and subjected to a fixed-pressure shock model (mean arterial pressure of 50 mmHg for 2 h), followed by resuscitation with either HSD (4 mL/kg) or lactated Ringer's solution (LR; 37 mL/kg). Mean arterial pressure was restored to 90%, cardiac output to 125% and 120%, and plasma volume to 78% and 72% of baseline in LR and HSD groups, respectively. Glomerular filtration rate improved to 100% of baseline following HSD compared with 82% following LR. No significant urinary 70,000 molecular weight dextran was observed, suggesting an intact renal glomerular membrane. These data suggest that small volume HSD resuscitation is effective, even with pre-existing dehydration. In addition, renal function is not compromised by HSD resuscitation of hemorrhaged, dehydrated animals.

Original languageEnglish (US)
Pages (from-to)289-297
Number of pages9
JournalShock
Volume5
Issue number4
StatePublished - Apr 1996

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Physiology

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    Ho, H. S., Sondeen, J. L., Dubick, M. A., Wade, C. E., & Gunther, R. A. (1996). The renal effects of 7.5% NaCl-6% dextran-70 versus lactated ringer's resuscitation of hemorrhage in dehydrated sheep. Shock, 5(4), 289-297.