Abstract
A small volume of 7.5% NaCl/6% Dextran-70 (HSD) can rapidly expand the plasma volume, but concerns exist regarding its adverse effects on renal function in the dehydrated state. Sheep were thirsted for 4 days (13% plasma volume contraction), and subjected to a fixed-pressure shock model (mean arterial pressure of 50 mmHg for 2 h), followed by resuscitation with either HSD (4 mL/kg) or lactated Ringer's solution (LR; 37 mL/kg). Mean arterial pressure was restored to 90%, cardiac output to 125% and 120%, and plasma volume to 78% and 72% of baseline in LR and HSD groups, respectively. Glomerular filtration rate improved to 100% of baseline following HSD compared with 82% following LR. No significant urinary 70,000 molecular weight dextran was observed, suggesting an intact renal glomerular membrane. These data suggest that small volume HSD resuscitation is effective, even with pre-existing dehydration. In addition, renal function is not compromised by HSD resuscitation of hemorrhaged, dehydrated animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 289-297 |
| Number of pages | 9 |
| Journal | Shock |
| Volume | 5 |
| Issue number | 4 |
| State | Published - Apr 1996 |
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ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
- Physiology
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The renal effects of 7.5% NaCl-6% dextran-70 versus lactated ringer's resuscitation of hemorrhage in dehydrated sheep. / Ho, Hung S; Sondeen, Jill L.; Dubick, Michael A.; Wade, Charles E.; Gunther, Robert A.
In: Shock, Vol. 5, No. 4, 04.1996, p. 289-297.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The renal effects of 7.5% NaCl-6% dextran-70 versus lactated ringer's resuscitation of hemorrhage in dehydrated sheep
AU - Ho, Hung S
AU - Sondeen, Jill L.
AU - Dubick, Michael A.
AU - Wade, Charles E.
AU - Gunther, Robert A.
PY - 1996/4
Y1 - 1996/4
N2 - A small volume of 7.5% NaCl/6% Dextran-70 (HSD) can rapidly expand the plasma volume, but concerns exist regarding its adverse effects on renal function in the dehydrated state. Sheep were thirsted for 4 days (13% plasma volume contraction), and subjected to a fixed-pressure shock model (mean arterial pressure of 50 mmHg for 2 h), followed by resuscitation with either HSD (4 mL/kg) or lactated Ringer's solution (LR; 37 mL/kg). Mean arterial pressure was restored to 90%, cardiac output to 125% and 120%, and plasma volume to 78% and 72% of baseline in LR and HSD groups, respectively. Glomerular filtration rate improved to 100% of baseline following HSD compared with 82% following LR. No significant urinary 70,000 molecular weight dextran was observed, suggesting an intact renal glomerular membrane. These data suggest that small volume HSD resuscitation is effective, even with pre-existing dehydration. In addition, renal function is not compromised by HSD resuscitation of hemorrhaged, dehydrated animals.
AB - A small volume of 7.5% NaCl/6% Dextran-70 (HSD) can rapidly expand the plasma volume, but concerns exist regarding its adverse effects on renal function in the dehydrated state. Sheep were thirsted for 4 days (13% plasma volume contraction), and subjected to a fixed-pressure shock model (mean arterial pressure of 50 mmHg for 2 h), followed by resuscitation with either HSD (4 mL/kg) or lactated Ringer's solution (LR; 37 mL/kg). Mean arterial pressure was restored to 90%, cardiac output to 125% and 120%, and plasma volume to 78% and 72% of baseline in LR and HSD groups, respectively. Glomerular filtration rate improved to 100% of baseline following HSD compared with 82% following LR. No significant urinary 70,000 molecular weight dextran was observed, suggesting an intact renal glomerular membrane. These data suggest that small volume HSD resuscitation is effective, even with pre-existing dehydration. In addition, renal function is not compromised by HSD resuscitation of hemorrhaged, dehydrated animals.
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M3 - Article
VL - 5
SP - 289
EP - 297
JO - Shock
JF - Shock
SN - 1073-2322
IS - 4
ER -