The relationship of urinary metabolites of carbaryl/naphthalene and chlorpyrifos with human semen quality

John D. Meeker, Louise Ryan, Dana B. Barr, Robert F. Herrick, Deborah H Bennett, Roberto Bravo, Russ Hauser

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between carbaryl exposure and decreased semen quality. In the present study we explored whether environmental exposures to 1-naphthol (1N), a metabolite of carbaryl and naphthalene, and 3,5,6-trichloro-2-pyridinol (TCPY), a metabolite of chlorpyrifos and chlorpyrifos-methyl, are associated with decreased semen quality in humans. Subjects (n = 272) were recruited through a Massachusetts infertility clinic. Individual exposures were measured as spot urinary concentrations of 1N and TCPY adjusted using specific gravity. Semen quality was assessed as sperm concentration, percent motile sperm, and percent sperm with normal morphology, along with sperm motion parameters (straight-line velocity, curvilinear velocity, and linearity). Median TCPY and 1N concentrations were 3.22 and 3.19 μg/L, respectively. For increasing 1N tertiles, adjusted odds ratios (ORs) were significantly elevated for below-reference sperm concentration (OR for low, medium, and high tertiles = 1.0, 4.2, 4.2, respectively; p-value for trend = 0.01) and percent motile sperm (1.0, 2.5, 2.4; p-value for trend = 0.01). The sperm motion parameter most strongly associated with 1N was straight-line velocity. There were suggestive, borderline-significant associations for TCPY with sperm concentration and motility, whereas sperm morphology was weakly and nonsignificantly associated with both TCPY and 1N. The observed associations between altered semen quality and 1N are consistent with previous studies of carbaryl exposure, although suggestive associations with TCPY are difficult to interpret because human and animal data are currently limited.

Original languageEnglish (US)
Pages (from-to)1665-1670
Number of pages6
JournalEnvironmental Health Perspectives
Volume112
Issue number17
DOIs
StatePublished - Dec 2004
Externally publishedYes

Fingerprint

Carbaryl
Chlorpyrifos
Semen Analysis
chlorpyrifos
Metabolites
naphthalene
sperm
Spermatozoa
metabolite
Animals
Odds Ratio
Specific Gravity
Insecticides
carbaryl
1-naphthol
Sperm Motility
infertility
Environmental Exposure
Laboratory Animals
Density (specific gravity)

Keywords

  • Biological markers
  • Environment
  • Human
  • Pesticides
  • Semen

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

The relationship of urinary metabolites of carbaryl/naphthalene and chlorpyrifos with human semen quality. / Meeker, John D.; Ryan, Louise; Barr, Dana B.; Herrick, Robert F.; Bennett, Deborah H; Bravo, Roberto; Hauser, Russ.

In: Environmental Health Perspectives, Vol. 112, No. 17, 12.2004, p. 1665-1670.

Research output: Contribution to journalArticle

Meeker, John D. ; Ryan, Louise ; Barr, Dana B. ; Herrick, Robert F. ; Bennett, Deborah H ; Bravo, Roberto ; Hauser, Russ. / The relationship of urinary metabolites of carbaryl/naphthalene and chlorpyrifos with human semen quality. In: Environmental Health Perspectives. 2004 ; Vol. 112, No. 17. pp. 1665-1670.
@article{bdfce42d4a1940cb9199c245be78ed4d,
title = "The relationship of urinary metabolites of carbaryl/naphthalene and chlorpyrifos with human semen quality",
abstract = "Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between carbaryl exposure and decreased semen quality. In the present study we explored whether environmental exposures to 1-naphthol (1N), a metabolite of carbaryl and naphthalene, and 3,5,6-trichloro-2-pyridinol (TCPY), a metabolite of chlorpyrifos and chlorpyrifos-methyl, are associated with decreased semen quality in humans. Subjects (n = 272) were recruited through a Massachusetts infertility clinic. Individual exposures were measured as spot urinary concentrations of 1N and TCPY adjusted using specific gravity. Semen quality was assessed as sperm concentration, percent motile sperm, and percent sperm with normal morphology, along with sperm motion parameters (straight-line velocity, curvilinear velocity, and linearity). Median TCPY and 1N concentrations were 3.22 and 3.19 μg/L, respectively. For increasing 1N tertiles, adjusted odds ratios (ORs) were significantly elevated for below-reference sperm concentration (OR for low, medium, and high tertiles = 1.0, 4.2, 4.2, respectively; p-value for trend = 0.01) and percent motile sperm (1.0, 2.5, 2.4; p-value for trend = 0.01). The sperm motion parameter most strongly associated with 1N was straight-line velocity. There were suggestive, borderline-significant associations for TCPY with sperm concentration and motility, whereas sperm morphology was weakly and nonsignificantly associated with both TCPY and 1N. The observed associations between altered semen quality and 1N are consistent with previous studies of carbaryl exposure, although suggestive associations with TCPY are difficult to interpret because human and animal data are currently limited.",
keywords = "Biological markers, Environment, Human, Pesticides, Semen",
author = "Meeker, {John D.} and Louise Ryan and Barr, {Dana B.} and Herrick, {Robert F.} and Bennett, {Deborah H} and Roberto Bravo and Russ Hauser",
year = "2004",
month = "12",
doi = "10.1289/ehp.7234",
language = "English (US)",
volume = "112",
pages = "1665--1670",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "Public Health Services, US Dept of Health and Human Services",
number = "17",

}

TY - JOUR

T1 - The relationship of urinary metabolites of carbaryl/naphthalene and chlorpyrifos with human semen quality

AU - Meeker, John D.

AU - Ryan, Louise

AU - Barr, Dana B.

AU - Herrick, Robert F.

AU - Bennett, Deborah H

AU - Bravo, Roberto

AU - Hauser, Russ

PY - 2004/12

Y1 - 2004/12

N2 - Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between carbaryl exposure and decreased semen quality. In the present study we explored whether environmental exposures to 1-naphthol (1N), a metabolite of carbaryl and naphthalene, and 3,5,6-trichloro-2-pyridinol (TCPY), a metabolite of chlorpyrifos and chlorpyrifos-methyl, are associated with decreased semen quality in humans. Subjects (n = 272) were recruited through a Massachusetts infertility clinic. Individual exposures were measured as spot urinary concentrations of 1N and TCPY adjusted using specific gravity. Semen quality was assessed as sperm concentration, percent motile sperm, and percent sperm with normal morphology, along with sperm motion parameters (straight-line velocity, curvilinear velocity, and linearity). Median TCPY and 1N concentrations were 3.22 and 3.19 μg/L, respectively. For increasing 1N tertiles, adjusted odds ratios (ORs) were significantly elevated for below-reference sperm concentration (OR for low, medium, and high tertiles = 1.0, 4.2, 4.2, respectively; p-value for trend = 0.01) and percent motile sperm (1.0, 2.5, 2.4; p-value for trend = 0.01). The sperm motion parameter most strongly associated with 1N was straight-line velocity. There were suggestive, borderline-significant associations for TCPY with sperm concentration and motility, whereas sperm morphology was weakly and nonsignificantly associated with both TCPY and 1N. The observed associations between altered semen quality and 1N are consistent with previous studies of carbaryl exposure, although suggestive associations with TCPY are difficult to interpret because human and animal data are currently limited.

AB - Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between carbaryl exposure and decreased semen quality. In the present study we explored whether environmental exposures to 1-naphthol (1N), a metabolite of carbaryl and naphthalene, and 3,5,6-trichloro-2-pyridinol (TCPY), a metabolite of chlorpyrifos and chlorpyrifos-methyl, are associated with decreased semen quality in humans. Subjects (n = 272) were recruited through a Massachusetts infertility clinic. Individual exposures were measured as spot urinary concentrations of 1N and TCPY adjusted using specific gravity. Semen quality was assessed as sperm concentration, percent motile sperm, and percent sperm with normal morphology, along with sperm motion parameters (straight-line velocity, curvilinear velocity, and linearity). Median TCPY and 1N concentrations were 3.22 and 3.19 μg/L, respectively. For increasing 1N tertiles, adjusted odds ratios (ORs) were significantly elevated for below-reference sperm concentration (OR for low, medium, and high tertiles = 1.0, 4.2, 4.2, respectively; p-value for trend = 0.01) and percent motile sperm (1.0, 2.5, 2.4; p-value for trend = 0.01). The sperm motion parameter most strongly associated with 1N was straight-line velocity. There were suggestive, borderline-significant associations for TCPY with sperm concentration and motility, whereas sperm morphology was weakly and nonsignificantly associated with both TCPY and 1N. The observed associations between altered semen quality and 1N are consistent with previous studies of carbaryl exposure, although suggestive associations with TCPY are difficult to interpret because human and animal data are currently limited.

KW - Biological markers

KW - Environment

KW - Human

KW - Pesticides

KW - Semen

UR - http://www.scopus.com/inward/record.url?scp=8344255263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8344255263&partnerID=8YFLogxK

U2 - 10.1289/ehp.7234

DO - 10.1289/ehp.7234

M3 - Article

C2 - 15579410

AN - SCOPUS:8344255263

VL - 112

SP - 1665

EP - 1670

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 17

ER -