TY - JOUR
T1 - The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients
AU - Salloway, Stephen
AU - Boyle, Patricia A.
AU - Correia, Stephen
AU - Malloy, Paul F.
AU - Cahn-Weiner, Deborah
AU - Schneider, Lon
AU - Krishnan, K. Ranga Rama
AU - Nakra, Raj
PY - 2002/1/1
Y1 - 2002/1/1
N2 - The authors examined differences in antidepressant treatment response in geriatric outpatients with high vs. low levels of magnetic resonance imaging (MRI)-defined subcortical hyperintensities (SH). Participants included 59 outpatients with mild-to-moderate depression (mean age: 69±5.63 years; mean Hamilton Rating Scale for Depression score: 21±2.88) who participated in a placebo-controlled trial of sertraline and underwent a standardized brain MRI. Results revealed that the high-SH group was significantly older than the low-SH group but, contrary to the hypothesis, antidepressant treatment response did not differ between the high- and low-SH groups. The association between SH and antidepressant treatment response in depressed geriatric outpatients remains unclear and deserves further investigation.
AB - The authors examined differences in antidepressant treatment response in geriatric outpatients with high vs. low levels of magnetic resonance imaging (MRI)-defined subcortical hyperintensities (SH). Participants included 59 outpatients with mild-to-moderate depression (mean age: 69±5.63 years; mean Hamilton Rating Scale for Depression score: 21±2.88) who participated in a placebo-controlled trial of sertraline and underwent a standardized brain MRI. Results revealed that the high-SH group was significantly older than the low-SH group but, contrary to the hypothesis, antidepressant treatment response did not differ between the high- and low-SH groups. The association between SH and antidepressant treatment response in depressed geriatric outpatients remains unclear and deserves further investigation.
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U2 - 10.1097/00019442-200201000-00013
DO - 10.1097/00019442-200201000-00013
M3 - Article
C2 - 11790641
AN - SCOPUS:0036143608
VL - 10
SP - 107
EP - 111
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
SN - 1064-7481
IS - 1
ER -