The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients

Stephen Salloway, Patricia A. Boyle, Stephen Correia, Paul F. Malloy, Deborah Cahn-Weiner, Lon Schneider, K. Ranga Rama Krishnan, Raj Nakra

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The authors examined differences in antidepressant treatment response in geriatric outpatients with high vs. low levels of magnetic resonance imaging (MRI)-defined subcortical hyperintensities (SH). Participants included 59 outpatients with mild-to-moderate depression (mean age: 69±5.63 years; mean Hamilton Rating Scale for Depression score: 21±2.88) who participated in a placebo-controlled trial of sertraline and underwent a standardized brain MRI. Results revealed that the high-SH group was significantly older than the low-SH group but, contrary to the hypothesis, antidepressant treatment response did not differ between the high- and low-SH groups. The association between SH and antidepressant treatment response in depressed geriatric outpatients remains unclear and deserves further investigation.

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalAmerican Journal of Geriatric Psychiatry
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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