The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients

Stephen Salloway; Patricia A. Boyle; Stephen Correia; Paul F. Malloy; Deborah Cahn-Weiner; Lon Schneider; K. Ranga Rama Krishnan; Raj Nakra

doi:10.1097/00019442-200201000-00013

The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients

Stephen Salloway, Patricia A. Boyle, Stephen Correia, Paul F. Malloy, Deborah Cahn-Weiner, Lon Schneider, K. Ranga Rama Krishnan, Raj Nakra

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The authors examined differences in antidepressant treatment response in geriatric outpatients with high vs. low levels of magnetic resonance imaging (MRI)-defined subcortical hyperintensities (SH). Participants included 59 outpatients with mild-to-moderate depression (mean age: 69±5.63 years; mean Hamilton Rating Scale for Depression score: 21±2.88) who participated in a placebo-controlled trial of sertraline and underwent a standardized brain MRI. Results revealed that the high-SH group was significantly older than the low-SH group but, contrary to the hypothesis, antidepressant treatment response did not differ between the high- and low-SH groups. The association between SH and antidepressant treatment response in depressed geriatric outpatients remains unclear and deserves further investigation.

Original language	English (US)
Pages (from-to)	107-111
Number of pages	5
Journal	American Journal of Geriatric Psychiatry
Volume	10
Issue number	1
DOIs	https://doi.org/10.1097/00019442-200201000-00013
State	Published - Jan 1 2002
Externally published	Yes

ASJC Scopus subject areas

Geriatrics and Gerontology
Psychiatry and Mental health

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Salloway, S., Boyle, P. A., Correia, S., Malloy, P. F., Cahn-Weiner, D., Schneider, L., Krishnan, K. R. R., & Nakra, R. (2002). The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients. American Journal of Geriatric Psychiatry, 10(1), 107-111. https://doi.org/10.1097/00019442-200201000-00013

The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients. / Salloway, Stephen; Boyle, Patricia A.; Correia, Stephen; Malloy, Paul F.; Cahn-Weiner, Deborah; Schneider, Lon; Krishnan, K. Ranga Rama; Nakra, Raj.

In: American Journal of Geriatric Psychiatry, Vol. 10, No. 1, 01.01.2002, p. 107-111.

Research output: Contribution to journal › Article › peer-review

Salloway, Stephen ; Boyle, Patricia A. ; Correia, Stephen ; Malloy, Paul F. ; Cahn-Weiner, Deborah ; Schneider, Lon ; Krishnan, K. Ranga Rama ; Nakra, Raj. / The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients. In: American Journal of Geriatric Psychiatry. 2002 ; Vol. 10, No. 1. pp. 107-111.

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The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients

Abstract

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