The relationship of estrogen receptor-α and -β genes with osteoarthritis of the hand

Barton L Wise, Serkalem Demissie, L. Adrienne Cupples, David T. Felson, Mei Yang, Amanda M. Shearman, Piran Aliabadi, David J. Hunter

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Objective. We examined reported associations between radiographic hand osteoarthritis (OA) and single-nucleotide polymorphisms (SNP) in 2 candidate genes associated with OA in other joints: estrogen receptor alpha (ESR1) and beta (ESR2). Methods. In 539 Framingham Offspring Study participants (49% men; mean age 61 ± 9 yrs) joint-specific radiographic hand OA was defined as Kellgren/Lawrence (K/L) scores ≥ 2 in the first carpometacarpal joint (CMC), distal interphalangeal joints (DIP), first-digit interphalangeal joint (IP), or proximal interphalangeal joints (PIP). Four SNP were genotyped for ESR1 (PvuII-rs2234693, XbaI-rs9340799, rs2077647, and rs1801132) and 4 for ESR2 (rs1256031, rs1256034, rs1256059, rs944460). Logistic regression analyses were performed to evaluate the relationships between genotypes and hand OA, adjusting for age, sex, height, and weight. Results. Radiographic hand OA was identified in at least one investigated joint of DIP (39%), PIP (33%), and first CMC (40%). There was no evidence of association between OAand genotype at any polymorphism. We found no significant association between our OA phenotypes or generalized or severe generalized OA as defined by Ushiyama and heterozygosity for rs2234693 and rs9340799, although in metaanalysis with the former study this heterozygosity remained significantly associated with generalized or severe generalized OA. Conclusion. We found no significant association between hand OA and the investigated polymorphisms of ESR1 or ESR2 despite published reports of association and a priori hypotheses implicating their potential roles. However, we could not absolutely exclude associations with rs2234693, rs9340799, or rs944460. The Journal of Rheumatology

Original languageEnglish (US)
Pages (from-to)2772-2779
Number of pages8
JournalJournal of Rheumatology
Issue number12
StatePublished - Dec 2009


  • Estrogen receptor genes
  • Framingham osteoarthritis study
  • Hand
  • Osteoarthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy


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