The relationship between systolic pressure and stroke volume describes myocardial contractility

J. A. Reitan, Peter G Moore, N. D. Kien, S. Lee, D. A. White

Research output: Contribution to journalArticle

Abstract

Objective: To develop a method of measuring end-systolic elastance from information obtained outside the ventricle and thereby simplify its transduction. Design: Prospective, within-animal comparative analysis. Setting: University-based laboratory study. Participants: Six mixed-breed dogs. Interventions: Instrumentation included minor axis sonomicrometry, ascending aortic flow probe, aortic and ventricular pressure transducers, and constricting cuffs on the vena cavae and aorta. Measurements and Main Results: Elastance was determined from the equation Pes = Ees(Ved - Ves), where Ved - Ves is stroke volume and Pes is end-systolic arterial pressure. Ees was derived from both preload and afterload manipulation. Cardiac performance indices were calculated automatically by computer under conditions of varying load and inotropy. This extraventricular method of elastance calculation was compared by linear regression and analysis of variance to preload recruitable stroke work, traditional Ees determination (using ventricular dimension instead of volume), and LVdP/dt at 50 mmHg. Ees measured from the aortic sites correlated well with the other contractility indicators (p < 0.003 in all cases) and demonstrated more sensitivity and stability under loading manipulation than traditional Ees. A strong relationship between the change in stroke volume and end-systolic ventricular diameter during acute aortic constriction (r = 0.924, p < 0.0001) was observed, and the mean r value for the individual outflow elastance measurements was 0.97 ± 0.02. Conclusions: In this study, measurement of Ees from the ventricular outflow tract during progressive aortic constriction produced results more consistent and descriptive than Ees by traditional techniques and has the potential for obtaining elastance measurements from possibly less invasive techniques.

Original languageEnglish (US)
Pages (from-to)676-683
Number of pages8
JournalJournal of Cardiothoracic and Vascular Anesthesia
Volume9
Issue number6
DOIs
StatePublished - 1995

Fingerprint

Constriction
Stroke Volume
Arterial Pressure
Blood Pressure
Pressure Transducers
Venae Cavae
Ventricular Pressure
Aorta
Linear Models
Analysis of Variance
Stroke
Regression Analysis
Dogs

Keywords

  • contractility
  • elastance
  • endsystole
  • measurement
  • myocardium

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

The relationship between systolic pressure and stroke volume describes myocardial contractility. / Reitan, J. A.; Moore, Peter G; Kien, N. D.; Lee, S.; White, D. A.

In: Journal of Cardiothoracic and Vascular Anesthesia, Vol. 9, No. 6, 1995, p. 676-683.

Research output: Contribution to journalArticle

Reitan, J. A. ; Moore, Peter G ; Kien, N. D. ; Lee, S. ; White, D. A. / The relationship between systolic pressure and stroke volume describes myocardial contractility. In: Journal of Cardiothoracic and Vascular Anesthesia. 1995 ; Vol. 9, No. 6. pp. 676-683.
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