The relationship between regional body composition and quantitative strength in facioscapulohumeral muscular dystrophy (FSHD)

Andrew J. Skalsky, Richard T. Abresch, Jay J. Han, Chris Shin, Craig M McDonald

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

This study determines in facioscapulohumeral muscular dystrophy (FSHD) and able-bodied controls (1) the regional body composition and (2) the correlation between regional lean tissue mass and the corresponding regional strength. This is a cross-sectional, criterion standard, case-control study at a university based neuromuscular disease clinic. A dual-energy X-ray absorptiometry (DEXA) scanner was used to obtain regional body composition measurements in 14 FSHD and anthropometrically matched control pairs. A dynamometer determined peak isometric strength for the elbow and knee. Compared to controls, FSHD subjects showed increased regional fat tissue mass (p < 0.001-0.017), decreased regional lean tissue mass (p < 0.001-0.010), and decreased strength (p < 0.001-0.020). There was a correlation between quantitative strength and lean tissue mass for both FSHD and controls (r = 0.791-0.906; p < 0.001). FSHD subjects have higher regional fat tissue mass and lower regional lean tissue mass despite similar BMI and anthropometrics. Regional lean tissue mass correlates with strength.

Original languageEnglish (US)
Pages (from-to)873-880
Number of pages8
JournalNeuromuscular Disorders
Volume18
Issue number11
DOIs
StatePublished - Nov 2008

Keywords

  • BMI
  • Body composition
  • DEXA
  • Dual-energy X-ray absorptiometry
  • Facioscapulohumeral muscular dystrophy
  • Fat tissue mass
  • Lean tissue mass
  • Muscle strength

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Genetics(clinical)
  • Neurology

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