The relationship between neuropsychological performance and daily functioning in individuals with Alzheimer's disease: Ecological validity of neuropsychological tests

Sarah E Tomaszewski Farias, Ernest Harrell, Craig Neumann, Andrew Houtz

Research output: Contribution to journalArticle

122 Scopus citations


The current study examined the relationship between neuropsychological test performance and functional status in 42 individuals diagnosed with Alzheimer's disease. A comprehensive battery of cognitive tests was employed in order to assess a wide range of neuropsychological abilities. Functional status was measured through the use of both a performance-based scale of activities of daily living (an expanded version of the Direct Assessment of Functional Status; DAFS, Loewenstein et al., 1989), and by a caregiver/informant-based rating scale (Instrumental Activities of Daily Living; IADL, Lawton & Brody, 1969). Findings suggest that neuropsychological functioning is moderately predictive of functional status. Using multiple regression analyses, neuropsychological variables accounted for 25% of the variance in the IADL and 50% of the variance in the DAFS. Individual domains of both functional measures were also significantly predicted by the neuropsychological variables. The findings provide evidence of a relationship between neuropsychological test performance and ADLs in an Alzheimer disease patient population.

Original languageEnglish (US)
Pages (from-to)655-672
Number of pages18
JournalArchives of Clinical Neuropsychology
Issue number6
StatePublished - Aug 2003



  • Alzheimer's disease
  • DAFS
  • IADL

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology
  • Neuropsychology and Physiological Psychology

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