The relationship between measures of obesity and incident heart failure: The multi-ethnic study of atherosclerosis

Imo A. Ebong, David C. Goff, Carlos J. Rodriguez, Haiying Chen, David A. Bluemke, Moyses Szklo, Alain G. Bertoni

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: To evaluate the strength of association of body mass index (BMI) and waist circumference (WC) with incident heart failure (HF), exploring our associations by ethnicity and age. Design and Methods: 6,809 participants, aged 45-84 years old, without clinical cardiovascular disease (2000-2002), from the Multi-Ethnic Study of Atherosclerosis were included. Cox-Proportional hazards models were used to examine associations of BMI and WC with incident HF. The predictive abilities of BMI and WC were compared using receiver operating characteristic curves. Results: Over a median follow-up of 7.6 years, there were 176 cases. BMI and WC were associated with incident HF in men (1.33 [1.10-1.61] and 1.38 [1.18-1.62], respectively] and women (1.70 [1.33-2.17] and 1.64 [1.29-2.08], respectively). These associations became non-significant after adjusting for obesity-related conditions (hypertension, dysglycemia, hypercholesterolemia, left ventricular hypertrophy, kidney disease, and inflammation). The associations of BMI and WC did not vary significantly by ethnicity or age-group, but were inverse in Hispanic men. The area under the curve for BMI and WC was 0.749 and 0.750, respectively, in men and 0.782 and 0.777, respectively, in women. Conclusions: The association between obesity and incident HF is largely mediated by obesity-related conditions. BMI and WC have similar predictive abilities for incident HF.

Original languageEnglish (US)
Pages (from-to)1915-1922
Number of pages8
JournalObesity
Volume21
Issue number9
DOIs
StatePublished - Sep 1 2013
Externally publishedYes

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Waist Circumference
Atherosclerosis
Body Mass Index
Heart Failure
Obesity
Kidney Diseases
Left Ventricular Hypertrophy
Hypercholesterolemia
Hispanic Americans
Proportional Hazards Models
ROC Curve
Area Under Curve
Cardiovascular Diseases
Age Groups
Hypertension
Inflammation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Ebong, I. A., Goff, D. C., Rodriguez, C. J., Chen, H., Bluemke, D. A., Szklo, M., & Bertoni, A. G. (2013). The relationship between measures of obesity and incident heart failure: The multi-ethnic study of atherosclerosis. Obesity, 21(9), 1915-1922. https://doi.org/10.1002/oby.20298

The relationship between measures of obesity and incident heart failure : The multi-ethnic study of atherosclerosis. / Ebong, Imo A.; Goff, David C.; Rodriguez, Carlos J.; Chen, Haiying; Bluemke, David A.; Szklo, Moyses; Bertoni, Alain G.

In: Obesity, Vol. 21, No. 9, 01.09.2013, p. 1915-1922.

Research output: Contribution to journalArticle

Ebong, IA, Goff, DC, Rodriguez, CJ, Chen, H, Bluemke, DA, Szklo, M & Bertoni, AG 2013, 'The relationship between measures of obesity and incident heart failure: The multi-ethnic study of atherosclerosis', Obesity, vol. 21, no. 9, pp. 1915-1922. https://doi.org/10.1002/oby.20298
Ebong, Imo A. ; Goff, David C. ; Rodriguez, Carlos J. ; Chen, Haiying ; Bluemke, David A. ; Szklo, Moyses ; Bertoni, Alain G. / The relationship between measures of obesity and incident heart failure : The multi-ethnic study of atherosclerosis. In: Obesity. 2013 ; Vol. 21, No. 9. pp. 1915-1922.
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