The relation between indel length and functional divergence: A formal study

Raheleh Salari, Alexander Schönhuth, Fereydoun Hormozdiari, Artem Cherkasov, S. Cenk Sahinalp

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Although insertions and deletions (indels) are a common type of evolutionary sequence variation, their origins and their functional consequences have not been comprehensively understood. There is evidence that, on one hand, classical alignment procedures only roughly reflect the evolutionary processes and, on the other hand, that they cause structural changes in the proteins' surfaces. We first demonstrate how to identify alignment gaps that have been introduced by evolution to a statistical significant degree, by means of a novel, sound statistical framework, based on pair hidden Markov models (HMMs). Second, we examine paralogous protein pairs in E. coli, obtained by computation of classical global alignments. Distinguishing between indel and non-indel pairs, according to our novel statistics, revealed that, despite having the same sequence identity, indel pairs are significantly less functionally similar than non-indel pairs, as measured by recently suggested GO based functional distances. This suggests that indels cause more severe functional changes than other types of sequence variation and that indel statistics should be taken into additional account to assess functional similarity between paralogous protein pairs.

Original languageEnglish (US)
Title of host publicationAlgorithms in Bioinformatics - 8th International Workshop, WABI 2008, Proceedings
Pages330-341
Number of pages12
DOIs
StatePublished - Nov 28 2008
Externally publishedYes
Event8th International Workshop on Algorithms in Bioinformatics, WABI 2008 - Karlsruhe, Germany
Duration: Sep 15 2008Sep 19 2008

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume5251 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other8th International Workshop on Algorithms in Bioinformatics, WABI 2008
CountryGermany
CityKarlsruhe
Period9/15/089/19/08

Keywords

  • Alignment statistics
  • Deletions
  • GO
  • Insertions
  • Pair Hidden Markov Models

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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