The regulation of tenascin expression by tissue microenvironments

Richard P Tucker, Ruth Chiquet-Ehrismann

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

Tenascins are a family of four extracellular matrix proteins: tenascin-C, X, R and W. The four members of the family have strikingly diverse patterns of expression during development and in the adult organism indicating independent mechanisms of regulation. In this review we illustrate that there are two types of tenascins, those that are significantly regulated by the tissue microenvironment (tenascin-C and tenascin-W), and those that have stabile, restricted expression patterns (tenascin-R and tenascin-X). We summarize what is known about the regulation of tenascin expression by transforming growth factor betas, fibroblast growth factors, platelet derived growth factors, as well as pro- and anti-inflammatory cytokines or hormones that either induce or inhibit expression of tenascins.

Original languageEnglish (US)
Pages (from-to)888-892
Number of pages5
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1793
Issue number5
DOIs
StatePublished - May 2009

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Keywords

  • Development
  • Extracellular matrix
  • Fibroblast growth factor
  • Growth factor
  • Transforming growth factor beta
  • Tumor stroma

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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