The regulation of burn-associated infections with herpes simplex virus type 1 or Candida albicans by a non-toxic aconitine-hydrolysate, benzoylmesaconine. Part 1: Antiviral and anti-fungal activities in thermally injured mice

Makiko Kobayashi, Kazuya Mori, Hiroyuki Kobayashi, Richard B Pollard, Fujio Suzuki

Research output: Contribution to journalArticle

20 Scopus citations


As compared with normal unburned mice, thermally injured mice have been shown to be 50-100 times more susceptible to HSV type 1 (HSV-1) or Candida albicans infection. Benzoylmesaconine (BEN) improved the resistance of thermally injured mice against infection with HSV-1 or C. albicans to the level observed in normal mice. Mortality rates of normal mice exposed to lethal amounts of these pathogens were not affected by the BEN treatment, while significant survival effects were produced in these mice after treatment with acyclovir (against HSV-1) or amphotericin B (against C. albicans). Benzoylmesaconine did not inhibit the growth of these pathogens in vitro and did not directly reduce the viability of the pathogens. However, burned mice inoculated with CD4+ T cells from BEN-treated mice resisted infections from these pathogens. These results suggested that, through the generation of CD4+ T cells, BEN recovered the impaired resistance of thermally injured mice to infection by HSV-1 or C. albicans.

Original languageEnglish (US)
Pages (from-to)202-208
Number of pages7
JournalImmunology and Cell Biology
Issue number3
StatePublished - 1998
Externally publishedYes



  • Benzoylmesaconine
  • Candida albicans
  • HSV
  • Thermal injury

ASJC Scopus subject areas

  • Immunology
  • Clinical Biochemistry
  • Cell Biology

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