Abstract
This article focuses on the emerging field of equine regenerative medicine with an emphasis on the use of mesenchymal stem cells (MSCs) for orthopedic diseases. We detail laboratory procedures and protocols for tissue handling and MSC isolation, characterization, expansion, and cryopreservation from bone marrow, fat, and placental tissues. We provide an overview of current clinical uses for equine MSCs and how MSCs function to heal tissues. Current laboratory practices in equine regenerative medicine mirror those in the human field. However, the translational use of autologous and allogeneic MSCs for patient therapy far exceeds what is currently permitted in human medicine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 109-123 |
| Number of pages | 15 |
| Journal | Clinics in Laboratory Medicine |
| Volume | 31 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 2011 |
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Keywords
- Equine
- Mesenchymal stem cell
- Orthopedic disease
- Regenerative medicine
- Stem cell
ASJC Scopus subject areas
- Biochemistry, medical
- Clinical Biochemistry
Cite this
The Regenerative Medicine Laboratory : Facilitating Stem Cell Therapy for Equine Disease. / Borjesson, Dori L; Peroni, John F.
In: Clinics in Laboratory Medicine, Vol. 31, No. 1, 03.2011, p. 109-123.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Regenerative Medicine Laboratory
T2 - Facilitating Stem Cell Therapy for Equine Disease
AU - Borjesson, Dori L
AU - Peroni, John F.
PY - 2011/3
Y1 - 2011/3
N2 - This article focuses on the emerging field of equine regenerative medicine with an emphasis on the use of mesenchymal stem cells (MSCs) for orthopedic diseases. We detail laboratory procedures and protocols for tissue handling and MSC isolation, characterization, expansion, and cryopreservation from bone marrow, fat, and placental tissues. We provide an overview of current clinical uses for equine MSCs and how MSCs function to heal tissues. Current laboratory practices in equine regenerative medicine mirror those in the human field. However, the translational use of autologous and allogeneic MSCs for patient therapy far exceeds what is currently permitted in human medicine.
AB - This article focuses on the emerging field of equine regenerative medicine with an emphasis on the use of mesenchymal stem cells (MSCs) for orthopedic diseases. We detail laboratory procedures and protocols for tissue handling and MSC isolation, characterization, expansion, and cryopreservation from bone marrow, fat, and placental tissues. We provide an overview of current clinical uses for equine MSCs and how MSCs function to heal tissues. Current laboratory practices in equine regenerative medicine mirror those in the human field. However, the translational use of autologous and allogeneic MSCs for patient therapy far exceeds what is currently permitted in human medicine.
KW - Equine
KW - Mesenchymal stem cell
KW - Orthopedic disease
KW - Regenerative medicine
KW - Stem cell
UR - http://www.scopus.com/inward/record.url?scp=79551501924&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79551501924&partnerID=8YFLogxK
U2 - 10.1016/j.cll.2010.12.001
DO - 10.1016/j.cll.2010.12.001
M3 - Article
C2 - 21295725
AN - SCOPUS:79551501924
VL - 31
SP - 109
EP - 123
JO - Clinics in Laboratory Medicine
JF - Clinics in Laboratory Medicine
SN - 0272-2712
IS - 1
ER -