The Regenerative Medicine Laboratory: Facilitating Stem Cell Therapy for Equine Disease

Dori L Borjesson; John F. Peroni

doi:10.1016/j.cll.2010.12.001

The Regenerative Medicine Laboratory: Facilitating Stem Cell Therapy for Equine Disease

Dori L Borjesson, John F. Peroni

Pathology, Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

This article focuses on the emerging field of equine regenerative medicine with an emphasis on the use of mesenchymal stem cells (MSCs) for orthopedic diseases. We detail laboratory procedures and protocols for tissue handling and MSC isolation, characterization, expansion, and cryopreservation from bone marrow, fat, and placental tissues. We provide an overview of current clinical uses for equine MSCs and how MSCs function to heal tissues. Current laboratory practices in equine regenerative medicine mirror those in the human field. However, the translational use of autologous and allogeneic MSCs for patient therapy far exceeds what is currently permitted in human medicine.

Original language	English (US)
Pages (from-to)	109-123
Number of pages	15
Journal	Clinics in Laboratory Medicine
Volume	31
Issue number	1
DOIs	https://doi.org/10.1016/j.cll.2010.12.001
State	Published - Mar 2011

Keywords

Equine
Mesenchymal stem cell
Orthopedic disease
Regenerative medicine
Stem cell

ASJC Scopus subject areas

Biochemistry, medical
Clinical Biochemistry

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10.1016/j.cll.2010.12.001

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abstract = "This article focuses on the emerging field of equine regenerative medicine with an emphasis on the use of mesenchymal stem cells (MSCs) for orthopedic diseases. We detail laboratory procedures and protocols for tissue handling and MSC isolation, characterization, expansion, and cryopreservation from bone marrow, fat, and placental tissues. We provide an overview of current clinical uses for equine MSCs and how MSCs function to heal tissues. Current laboratory practices in equine regenerative medicine mirror those in the human field. However, the translational use of autologous and allogeneic MSCs for patient therapy far exceeds what is currently permitted in human medicine.",

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AB - This article focuses on the emerging field of equine regenerative medicine with an emphasis on the use of mesenchymal stem cells (MSCs) for orthopedic diseases. We detail laboratory procedures and protocols for tissue handling and MSC isolation, characterization, expansion, and cryopreservation from bone marrow, fat, and placental tissues. We provide an overview of current clinical uses for equine MSCs and how MSCs function to heal tissues. Current laboratory practices in equine regenerative medicine mirror those in the human field. However, the translational use of autologous and allogeneic MSCs for patient therapy far exceeds what is currently permitted in human medicine.

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The Regenerative Medicine Laboratory: Facilitating Stem Cell Therapy for Equine Disease

Abstract

Keywords

ASJC Scopus subject areas

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