The Regenerative Medicine Laboratory: Facilitating Stem Cell Therapy for Equine Disease

Dori L Borjesson, John F. Peroni

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

This article focuses on the emerging field of equine regenerative medicine with an emphasis on the use of mesenchymal stem cells (MSCs) for orthopedic diseases. We detail laboratory procedures and protocols for tissue handling and MSC isolation, characterization, expansion, and cryopreservation from bone marrow, fat, and placental tissues. We provide an overview of current clinical uses for equine MSCs and how MSCs function to heal tissues. Current laboratory practices in equine regenerative medicine mirror those in the human field. However, the translational use of autologous and allogeneic MSCs for patient therapy far exceeds what is currently permitted in human medicine.

Original languageEnglish (US)
Pages (from-to)109-123
Number of pages15
JournalClinics in Laboratory Medicine
Volume31
Issue number1
DOIs
StatePublished - Mar 2011

Keywords

  • Equine
  • Mesenchymal stem cell
  • Orthopedic disease
  • Regenerative medicine
  • Stem cell

ASJC Scopus subject areas

  • Biochemistry, medical
  • Clinical Biochemistry

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